Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H23N5O2S |
| Molecular Weight | 361.462 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=NC2=C(N)N=C3C=CC=CC3=C2N1CCCCNS(C)(=O)=O
InChI
InChIKey=YZOQZEXYFLXNKA-UHFFFAOYSA-N
InChI=1S/C17H23N5O2S/c1-3-14-21-15-16(12-8-4-5-9-13(12)20-17(15)18)22(14)11-7-6-10-19-25(2,23)24/h4-5,8-9,19H,3,6-7,10-11H2,1-2H3,(H2,18,20)
CPG-52852 (PF-04878691) is a toll-like receptor 7 (TRL7) agonist. The drug was developed by 3M Pharmaceuticals and the Coley Pharmaceutical Group and was investigated in a number of clinical trials in patients with advanced cancer. Sustained tolerability and modest clinical benefit were demonstrated in heavily pretreated recurrent breast, ovarian, and cervix cancers. After Coley was acquired by Pfizer in 2007, the drug was repurposed for the treatment of hepatitis C. A phase 1 clinical trial was conducted. The development of the compound was discontinued because the compound was believed to unlikely to achieve the proof-of-concept criteria as a result of pharmacodynamic modeling.
Approval Year
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Code | English |
| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
218105
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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FDA ORPHAN DRUG |
176603
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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| Code System | Code | Type | Description | ||
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6PJC3KPK6S
Created by
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C61104
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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532959-63-0
Created by
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300000042572
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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10309114
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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DTXSID20201416
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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DB12476
Created by
admin on Mon Mar 31 18:03:52 GMT 2025 , Edited by admin on Mon Mar 31 18:03:52 GMT 2025
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PRIMARY |
ACTIVE MOIETY
