Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H12N4O.ClH |
| Molecular Weight | 216.668 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC1=NOC(=N1)C2CNC=NC2
InChI
InChIKey=FVWAMONNJGNNHY-UHFFFAOYSA-N
InChI=1S/C8H12N4O.ClH/c1-2-7-11-8(13-12-7)6-3-9-5-10-4-6;/h5-6H,2-4H2,1H3,(H,9,10);1H
MCD-386CR (CDD-0102A) is a functionally selective agonist with partial agonist activity at M1 muscarinic receptors, weak activity at M3 receptors, and no activity at other muscarinic receptor subtypes. In preclinical studies, it enhances memory function in animal models of Alzheimer's disease. MCD-386CR (CDD-0102A) received orphan drug designation from FDA in 2011. The drug is intended to treat progressive supranuclear palsy, a degenerative brain disease that affects balance, walking, speech, cognition, and eye movements.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The selective M1 muscarinic cholinergic agonist CDD-0102A enhances working memory and cognitive flexibility. | 2012-03 |
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| The utility of muscarinic agonists in the treatment of Alzheimer's disease. | 2002-09-06 |
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| Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors. | 2000-03 |
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| Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. | 1993-04-02 |
Patents
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| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
327510
Created by
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6P87MRR8OA
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44472513
Created by
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1196130-86-5
Created by
admin on Mon Mar 31 20:17:45 GMT 2025 , Edited by admin on Mon Mar 31 20:17:45 GMT 2025
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ACTIVE MOIETY
SUBSTANCE RECORD
