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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3.ClH
Molecular Weight 335.825
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METOPON HYDROCHLORIDE

SMILES

Cl.[H][C@]12CC3=CC=C(O)C4=C3[C@]5(CCN1C)[C@@]2([H])CCC(=O)[C@]5(C)O4

InChI

InChIKey=IUIZPWPENLRTFZ-RNWHKREASA-N
InChI=1S/C18H21NO3.ClH/c1-17-14(21)6-4-11-12-9-10-3-5-13(20)16(22-17)15(10)18(11,17)7-8-19(12)2;/h3,5,11-12,20H,4,6-9H2,1-2H3;1H/t11-,12+,17-,18-;/m0./s1

HIDE SMILES / InChI

Description

Metopon was developed as an analgesic opium derivative. This drug has a high affinity to the mu-opioid receptor and produces antinociception through this receptor. Metopon was available in Canada only in tablet form for oral administration; however, because of the drug addiction, the Drug Addiction Committee recommended its limited use.

Originator

Approval Year

1947
99
Sourcing

Sourcing

Vendor/AggregatorIDURL
HongKong Chemhere
SCA54164
NovoSeek
5359353
Toronto Research Chemicals
M567890
ZINC
ZINC000003875958
http://zinc15.docking.org/substances/ZINC000003875958
PubMed

PubMed

TitleDatePubMed
Metopon hydrochloride (methyldihydromorphinone hydrochloride).
1948 Jan
Patents

Patents

JP2002541233A
400
JP2003515526A
462
JP2005520783A
40
JP2005530798A
42
JP2006501241A
15
JP2007507532A
34
JP4642467B2
32
JP4695395B2
5

Sample Use Guides

In Vivo Use Guide
Metopon will be available in Canada only in tablet form for oral administration. The tablets will be put up in bottles of 50 and each tablet will contain 8.0 mgm. of metopon hydrochloride.
Route of Administration: Oral
Name Type Language
METOPON HYDROCHLORIDE
MI   WHO-DD  
Common Name English
5-METHYLDIHYDROMORPHINONE, HYDROCHLORIDE
Common Name English
Metopon hydrochloride [WHO-DD]
Common Name English
METOPON HCL
Common Name English
METHYLDIHYDROMORPHINONE HYDROCHLORIDE
Common Name English
METOPON HYDROCHLORIDE [MI]
Common Name English
(5.ALPHA.)-4,5-EPOXY-3-HYDROXY-5,17-DIMETHYLMORPHINAN-6-ONE HYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
DEA NO. 9260
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
NCI_THESAURUS C67413
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2110992
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
CAS
124-92-5
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
MERCK INDEX
m7497
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID10154184
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
NCI_THESAURUS
C83964
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
MESH
C046877
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
FDA UNII
6O34Q1K8M6
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
PUBCHEM
16057830
Created by admin on Fri Dec 15 14:59:38 GMT 2023 , Edited by admin on Fri Dec 15 14:59:38 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of METOPON
NIH
NCATS
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