GW-3965

Details

Stereochemistry	ACHIRAL
Molecular Formula	C33H31ClF3NO3
Molecular Weight	582.052
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F)=C1

InChI

InChIKey=NAXSRXHZFIBFMI-UHFFFAOYSA-N

InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
LXR-beta 6 Target ID: CHEMBL4093 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22406419	Agonist 2678		5.0 nM [EC50]
LXR-alpha 10 Target ID: CHEMBL2808 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22406419	Agonist 2678		22.0 nM [EC50]

PubMed

Title	Date	PubMed
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.	2002 May 9	11985463
Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice.	2005 Jan	15633131
GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats.	2007 Jun	17420776
Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes.	2012 Nov 23	23041609

Patents

Name

Type

Language

GW-3965

Common Name

English

3-(3-(N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)(2,2-DIPHENYLETHYL)AMINO)PROPOXY)PHENYLACETIC ACID

Systematic Name

English

BENZENEACETIC ACID, 3-(3-(((2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)METHYL)(2,2-DIPHENYLETHYL)AMINO)PROPOXY)-

Systematic Name

English

GW-3965A

Code

English

Code System Code Type Description

CAS

475207-20-6