Details
Stereochemistry | ACHIRAL |
Molecular Formula | C33H31ClF3NO3 |
Molecular Weight | 582.052 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F)=C1
InChI
InChIKey=NAXSRXHZFIBFMI-UHFFFAOYSA-N
InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4093 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22406419 |
5.0 nM [EC50] | ||
Target ID: CHEMBL2808 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22406419 |
22.0 nM [EC50] |
PubMed
Title | Date | PubMed |
---|---|---|
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. | 2002 May 9 |
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Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. | 2005 Jan |
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GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. | 2007 Jun |
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Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes. | 2012 Nov 23 |
Patents
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Code | English |
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475207-20-6
Created by
admin on Sat Dec 16 08:26:32 GMT 2023 , Edited by admin on Sat Dec 16 08:26:32 GMT 2023
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6JI5YOG7RC
Created by
admin on Sat Dec 16 08:26:32 GMT 2023 , Edited by admin on Sat Dec 16 08:26:32 GMT 2023
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447905
Created by
admin on Sat Dec 16 08:26:32 GMT 2023 , Edited by admin on Sat Dec 16 08:26:32 GMT 2023
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DTXSID60961002
Created by
admin on Sat Dec 16 08:26:32 GMT 2023 , Edited by admin on Sat Dec 16 08:26:32 GMT 2023
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405911-09-3
Created by
admin on Sat Dec 16 08:26:32 GMT 2023 , Edited by admin on Sat Dec 16 08:26:32 GMT 2023
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DB03791
Created by
admin on Sat Dec 16 08:26:32 GMT 2023 , Edited by admin on Sat Dec 16 08:26:32 GMT 2023
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PRIMARY |
ACTIVE MOIETY