Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H23N5O3S |
| Molecular Weight | 401.483 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1N(CCCCN2CCN(CC2)C3=NC=CC=N3)S(=O)(=O)C4=C1C=CC=C4
InChI
InChIKey=TZJUVVIWVWFLCD-UHFFFAOYSA-N
InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. | 1998 Aug 21 |
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| Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. | 1998 Mar |
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| Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies. | 2002 Dec |
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| Effects of ethanol and 5-HT1A agonists on astroglial S100B. | 2002 Dec 15 |
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| Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression. | 2002 Dec 15 |
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| Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors. | 2002 Feb-Nov |
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| Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects. | 2002 Nov |
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| Effects of ethanol and ipsapirone on the development of midline raphe glial cells and astrocytes. | 2003 Apr |
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| Modulation of 5-HT(1A) receptor-mediated Ca(2+) responses by co-expression with various recombinant G(alpha) proteins in CHO-K1 cells. | 2003 Aug |
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| Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress. | 2003 Feb 14 |
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| 5-HT1A responsivity in patients with panic disorder before and after treatment with aerobic exercise, clomipramine or placebo. | 2003 May |
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| Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil. | 2003 May 15 |
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| Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation. | 2003 Nov |
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| Effects of serotonin 5-HT(1/2) receptor agonists in a limited-access operant food intake paradigm in the rat. | 2003 Oct |
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| The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons. | 2004 Jun 21 |
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| New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation. | 2004 May 6 |
|
| Differential effects of the novel antidepressant agomelatine (S 20098) versus fluoxetine on 5-HT1A receptors in the rat brain. | 2004 Sep |
|
| Efficacy of open-label venlafaxine in subjects with major depressive disorder: associations with neuroendocrine response to serotonergic and noradrenergic probes. | 2004 Sep 30 |
|
| Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice. | 2005 Dec |
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| 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. | 2005 Dec 5 |
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| Gender-specific 5-HT1A receptor changes in BrdU nuclear labeling patterns in neonatal dentate gyrus. | 2005 Jun 9 |
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| Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. | 2005 Nov 29 |
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| Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. | 2005 Oct |
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| The 5-HT1A receptor and the stimulus effects of LSD in the rat. | 2005 Oct |
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| Differential effects of acute diazepam on emotional and neutral memory tasks in acutely hospitalized depressed patients. | 2005 Sep |
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| Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder. | 2005 Sep |
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| Signaling pathways involved with serotonin1A agonist-mediated neuroprotection against ethanol-induced apoptosis of fetal rhombencephalic neurons. | 2005 Sep 8 |
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| Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients. | 2006 Jan |
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| Azapirones for generalized anxiety disorder. | 2006 Jul 19 |
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| Gateways to clinical trials. | 2006 Jun |
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| Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. | 2006 Mar 27 |
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| The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons. | 2006 May 30 |
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| Temperature regulation in depression: functional 5HT1A receptor adaptation differentiates antidepressant response. | 2006 Oct |
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| A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. | 2007 Dec |
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| Prediction and prevention of suicide in patients with unipolar depression and anxiety. | 2007 Sep 5 |
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| Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. | 2008 Dec |
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| Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice. | 2008 Dec |
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| Antiaversive effects of cannabinoids: is the periaqueductal gray involved? | 2009 |
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| Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains. | 2009 Dec 15 |
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| 5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor. | 2009 Feb |
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| Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. | 2009 Jan 16 |
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| Cannabis and schizophrenia spectrum disorders: a review of clinical studies. | 2009 Jul |
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| 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials. | 2009 Jun |
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| Buspirone improves haloperidol-induced Parkinson disease in mice through 5-HT(1A) recaptors. | 2010 |
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| Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. | 2010 |
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| Modifying 5-HT1A Receptor Gene Expression as a New Target for Antidepressant Therapy. | 2010 |
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| Serotonin synthesis, release and reuptake in terminals: a mathematical model. | 2010 Aug 19 |
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| Cellular and mitochondrial effects of alcohol consumption. | 2010 Dec |
|
| Cortisol responses to ipsapirone challenge correlate with aggression, while basal cortisol levels correlate with impulsivity, in personality disorder and healthy volunteer subjects. | 2010 Oct |
|
| A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation. | 2010 Sep |
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C47794
Created by
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NCI_THESAURUS |
C28197
Created by
admin on Fri Dec 15 15:29:11 GMT 2023 , Edited by admin on Fri Dec 15 15:29:11 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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95847-70-4
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5774
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C043077
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m6395
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DTXSID4045688
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6J9B11MN0K
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100000083148
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CHEMBL8412
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IPSAPIRONE
Created by
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56971
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C74391
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SUB08290MIG
Created by
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
