Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H14N2 |
Molecular Weight | 162.2316 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNCC\C=C\C1=CN=CC=C1
InChI
InChIKey=JUOSGGQXEBBCJB-GORDUTHDSA-N
InChI=1S/C10H14N2/c1-11-7-3-2-5-10-6-4-8-12-9-10/h2,4-6,8-9,11H,3,7H2,1H3/b5-2+
Rivanicline (also known as RJR-2403 or TC-2403) is a partial neuronal nicotinic acetylcholine receptor agonist. This compound binds primarily to the α4β2 receptor subtype. Rivanicline was originally developed for Alzheimer’s disease and shows pronounced anti-amnesic and increased recognition memory in rats. Because rivanicline also inhibits Interleukin-8 production, it has been further developed as a potential anti-inflammatory treatment for ulcerative colitis (in which nicotine is of therapeutic value but has adverse events). Rivanicline effectively inhibited TNF- and LPS-induced IL-8 production in different cell types, without toxic effects. Rivanicline was also evaluated as a potential compound for the development of nicotinic therapeutics to treat neurological diseases in cases of compromised cholinergic neurotransmission.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1907589 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14698195 |
25.0 nM [Ki] | ||
Target ID: CHEMBL1907594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9435889 |
46.0 µM [EC50] |
PubMed
Title | Date | PubMed |
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RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. | 1996 Dec |
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RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. | 1996 Dec |
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Synthesis of (+/-)-methyl-(1-aryl-4-pyridin-3-yl-but-3-enyl)-amines. | 2001 Dec |
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Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. | 2002 Jun |
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3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors. | 2004 Jan 19 |
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Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia. | 2006 Dec |
Patents
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C73579
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C012419
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C66518
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RIVANICLINE
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DB05855
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5310967
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)