Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C28H29N7O |
| Molecular Weight | 479.5762 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(NC2=NC(=CC=N2)C3=CC=CN=C3)C=C(NC(=O)C4=CC=C(CN5CCNCC5)C=C4)C=C1
InChI
InChIKey=BQQYXPHRXIZMDM-UHFFFAOYSA-N
InChI=1S/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34)
DescriptionCurator's Comment: Description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/22865010
Curator's Comment: Description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/22865010
CGP-74588 (Norimatinib, N-Desmethyl Imatinib) is a metabolite of Imatinib, a tyrosine kinase inhibitor, displaying specificity for BCR-ABL. CGP-74588 is pharmacologically active, and shows a similar potency and selectivity profile as the parent drug
CNS Activity
Originator
Approval Year
Sample Use Guides
The effects of CGP74588 on BCR-ABL1 autophosphorylation and on BCR-ABL1-dependent cell viability were determined in murine haematopoietic Ba/F3 cells transfected to express human BCR-ABL1, using a capture enzyme-linked immunosorbant (ELISA) and a luminescence ATP-detection assay. CGP74588 shows potent inhibition of BCR-ABL in nanomolar range.
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DTXSID80193500
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admin on Sat Dec 16 08:43:29 GMT 2023 , Edited by admin on Sat Dec 16 08:43:29 GMT 2023
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6GOH0N63QD
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404844-03-7
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9869737
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404844-02-6
Created by
admin on Sat Dec 16 08:43:29 GMT 2023 , Edited by admin on Sat Dec 16 08:43:29 GMT 2023
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PARENT (METABOLITE ACTIVE)
SUBSTANCE RECORD
