SODELGLITAZAR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H21F4NO3S2
Molecular Weight	499.541
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CSC2=CC=C(OC(C)(C)C(O)=O)C(C)=C2)SC(=N1)C3=CC=C(C=C3F)C(F)(F)F

InChI

InChIKey=ZUGQWAYOWCBWGM-UHFFFAOYSA-N

InChI=1S/C23H21F4NO3S2/c1-12-9-15(6-8-18(12)31-22(3,4)21(29)30)32-11-19-13(2)28-20(33-19)16-7-5-14(10-17(16)24)23(25,26)27/h5-10H,11H2,1-4H3,(H,29,30)

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Description
Sources: https://adisinsight.springer.com/drugs/800018093 | https://www.ncbi.nlm.nih.gov/pubmed/21592078 | https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C75193

Sodelglitazar is an oral insulin sensitiser, a peroxisome proliferator-activated receptor (PPAR) pan agonist that was under development with GlaxoSmithKline for the treatment of hyperlipidaemia, type 2 diabetes mellitus and metabolic syndrome. Sodelglitazar exerts higher binding affinity for the delta subtype as compared to gamma and alpha subtypes. Sodelglitazar was being investigated in Phase II clinical trials for the treatment of T2DM and its complications, but this research has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor 5 Target ID: CHEMBL3559683 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21592078	Agonist 2678

PubMed

Title	Date	PubMed
Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar.	2011 Oct	21592078

Patents

Sample Use Guides

In Vivo Use Guide

Type 2 Diabetes Mellitus: oral capsules (15 mg)

Route of Administration: Oral

Name

Type

Language

SODELGLITAZAR

Official Name

English

GW677954

Code

English

2-[4-[[[2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methyl]sulfanyl]-2-methylphenoxy]-2-methylpropanoic acid

Systematic Name

English

GW-677954

Code

English

SODELGLITAZAR [USAN]

Common Name

English

sodelglitazar [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98233