U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Tetraglycine hydroperiodide is an iodine-containing chemical, used for water purification. Tetraglycine hydroperiodide is marketed in tablets; each tablet effectively disinfects 1 liter of clear water or 0.5 liter of tainted water by releasing approximately 8 mg free iodine. It requires approximately 30 minutes to inactivate target microorganisms and make water bacteriologically suitable for drinking. To remove iodine taste, a vitamin C pill is added to the kit.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Surgicide

Approved Use

Surgicide is a broad spectrum topical antiseptic for use on skin and mucous membranes. Use solution without dilution as needed
PubMed

PubMed

TitleDatePubMed
Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus.
2014-08
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
2012-09-01
The effects of ammonium perchlorate on thyroid homeostasis and thyroid-specific gene expression in rat.
2012-08
A blinded, randomized, palatability study comparing variations of 2 popular field water disinfection tablets.
2011-12
I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.
2011-07
Use of gadolinium for carotid artery angiography and stenting in patients with renal insufficiency.
2009-12
[The effects of iodine/selenium on the function of antigen presentation of peritoneal macrophages in rats].
2008-07
Gadolinium and kidney disease: are your patients at risk?
2008-05-14
[Suggestions for prevention of adverse reactions after intravasal administration of iodinated contrast media].
2008
Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC).
2007-11
Comparison of the usefulness of gadodiamide and iodine mixture versus iodinated contrast alone for prevention of contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angiography.
2007-10-01
Sodium iodide symporter is expressed at the preneoplastic stages of liver carcinogenesis and in human cholangiocarcinoma.
2007-04
[Effects of iodine excess and selenium supplement on the levels of thyroid hormone and its receptor expression in filial cerebrum of mice].
2007-03
Enhanced expression of adenovirus-mediated sodium iodide symporter gene in MCF-7 breast cancer cells with retinoic acid treatment.
2007-03
Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web.
2007-01
Comparative cytotoxicity of high-osmolar and low-osmolar contrast media on HKCs in vitro.
2006-12-19
Antiseptics, iodine, povidone iodine and traumatic wound cleansing.
2006-11
The treatment of Graves' disease in children.
2006-09
Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation.
2006-08-01
Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake.
2006-08
Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway.
2006-07-14
Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire.
2006-07
The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.
2006-03
Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine.
2005-11
Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma.
2005-10
[Effect of high-iodine intake on MBP mRNA expression in cerebrum of filial mice and selenium intervention].
2005-07
Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion.
2005-05-31
Thyrotropin-secreting pituitary adenoma responsive to bromocriptine therapy.
2004-07-15
Studies on experimental iodine allergy: 3. Low molecular weight elicitogenic antigens of iodine allergy.
2004-05
Thiocyanate induces cell necrosis and fibrosis in selenium- and iodine-deficient rat thyroids: a potential experimental model for myxedematous endemic cretinism in central Africa.
2004-02
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
2003-04
Functional expression of sodium iodide symporter (NIS) in human breast cancer tissue.
2003-01
Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.
2002-06
Effects of selenium and iodine on c-fos and c-jun mRNA and their protein expressions in cultured rat hippocampus cells.
2002
Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin.
2001-02
Anti-goitrous effect of lecithin-bound iodine in propylthiouracil treated rats.
2000-06
Adverse reactions to nonionic iodine in contrast-enhanced computed tomography: usefulness of monitoring vital signs.
1998-07
Propylthiouracil-induced rapidly progressive glomerulonephritis associated with antineutrophil cytoplasmic autoantibodies.
1997-07
Case report: reversible mitral regurgitation and congestive heart failure complicating thyrotoxicosis.
1996-03
Thyroid adaptation to chronic tetraglycine hydroperiodide water purification tablet use.
1995-01
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
1994-06
[Necrotizing hepatitis with a fatal outcome after carbimazole therapy].
1993-10-22
The susceptibility of the fetus and child to chemical pollutants. Special susceptibility of the host to chemical agents: endocrinologic considerations.
1974-05
Patents

Patents

Name Type Language
IODINE POVACRYLEX
ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
DURAPREP COMPONENT IODINE POVACRYLEX
Preferred Name English
METHYL 2-METHYLPROP-2-ENOATE POLYMER WITH 1-ETHENYLPYRROLIDIN-2-ONE AND ISOOCTYL PROP-2-ENOATE COMPOUND WITH DIIODINE AND SODIUM IODIDE
Common Name English
Iodine povacrylex [WHO-DD]
Common Name English
IODINE POVACRYLEX [USAN]
Common Name English
IODINE POVACRYLEX [ORANGE BOOK]
Common Name English
2-PROPENOIC ACID, 2-METHYL-, METHYL ESTER, POLYMER WITH 1-ETHENYL-2-PYRROLIDINONE AND ISOOCTYL 2-PROPENOATE, COMPOUND WITH IODINE AND SODIUM IODIDE (NAI)
Common Name English
Code System Code Type Description
FDA UNII
6E43AWY083
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
EPA CompTox
DTXSID501027731
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
RXCUI
692863
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY RxNorm
NCI_THESAURUS
C166931
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
USAN
RR-25
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
DRUG BANK
DB09537
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
CAS
845736-10-9
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
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DAILYMED
6E43AWY083
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
SMS_ID
300000044487
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
PRIMARY
ChEMBL
CHEMBL1201721
Created by admin on Mon Mar 31 21:56:29 GMT 2025 , Edited by admin on Mon Mar 31 21:56:29 GMT 2025
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Display Structure of IODINE POVACRYLEX