Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C24H29O5.Na |
Molecular Weight | 420.4738 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 6 / 6 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)[C@@H](C)CC#CC)[C@@]1([H])C3=C(O2)C(CCCC([O-])=O)=CC=C3
InChI
InChIKey=YTCZZXIRLARSET-ZTWNIFTGSA-M
InChI=1S/C24H30O5.Na/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28;/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28);/q;+1/p-1/b13-12+;/t15-,17-,19+,20+,21-,23-;/m0./s1
Esuberaprost (314d) is an active enantiomer of beraprost, a prostacyclin analog. The pharmacologic action of esuberaprost is mediated by specifically binding to PGI2 receptors in smooth muscle cells (the blood vessel’s endothelium) and platelets. Upon binding, the compound widened blood vessels, preventing the formation of blood clots, and lowering blood pressure in the lungs. As a result, it was expected to improve the symptoms of pulmonary arterial hypertension. United Therapeutics announced it has ended its Phase 3 BEAT trial testing esuberaprost as an add-on therapy to its product Tyvaso (inhaled treprostinil) for clinically symptomatic patients with pulmonary arterial hypertension (PAH). According to a company press release, the study failed to reach its main endpoint of delaying the time to first clinical worsening events.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets. | 1989 Apr |
|
Pharmacokinetics and platelet antiaggregating effects of beraprost, an oral stable prostacyclin analogue, in healthy volunteers. | 1993 Nov |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT01908699
Phase III study: 15 μg tablets for oral, 1 or 2 tablets four times daily (QID) administration
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
FDA ORPHAN DRUG |
355711
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
152695-53-9
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
C166926
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
AB-81
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
71587534
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
CHEMBL3137314
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
100000177220
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
DTXSID20165105
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY | |||
|
6C8TLD4Q9K
Created by
admin on Sat Dec 16 06:34:51 GMT 2023 , Edited by admin on Sat Dec 16 06:34:51 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD