| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H14O4 |
| Molecular Weight | 258.2693 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2C=CC(C)(C)OC2=CC3=C1C=CC(=O)O3
InChI
InChIKey=JSJIIHRNDMLJGK-UHFFFAOYSA-N
InChI=1S/C15H14O4/c1-15(2)7-6-10-12(19-15)8-11-9(14(10)17-3)4-5-13(16)18-11/h4-8H,1-3H3
Xanthoxyletin is a coumarin isolated from Erythrina variegata. It has been reported that Xanthoxyletin possesses antibacterial, fungicidal, and algicidal properties. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells. Xanthoxyletin may be promising anticancer agent and has worth for further mechanistic and therapeutic studies against gastric cancer.
Approval Year
Sample Use Guides
After treating the SGC-7901 cells
with 200 and 400 uM of Xanthoxyletin for 48 h, ROS
production was detected and the ratios of DCF-positive
cells were 18.66% and 32.86% respectively as compared
to 8.27% in the control group. Xanthoxyletin
induced apoptosis in SGC-7901 cells and percentage of
apoptotic cells was 41.47% after the exposure of 400 uM
of Xanthoxyletin for 48 h as compared to 2.6% in the
control group.
SUBSTANCE RECORD
