UZARIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C35H54O14
Molecular Weight	698.7949
Optical Activity	UNSPECIFIED
Defined Stereocenters	18 / 18
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](CC[C@]34C)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@]1(O)CC[C@@H]2C7=CC(=O)OC7

InChI

InChIKey=RIPMDUQTRRLJTE-QHYHXNCWSA-N

InChI=1S/C35H54O14/c1-33-8-5-18(46-32-30(28(42)26(40)23(14-37)48-32)49-31-29(43)27(41)25(39)22(13-36)47-31)12-17(33)3-4-21-20(33)6-9-34(2)19(7-10-35(21,34)44)16-11-24(38)45-15-16/h11,17-23,25-32,36-37,39-44H,3-10,12-15H2,1-2H3/t17-,18-,19+,20-,21+,22+,23+,25+,26+,27-,28-,29+,30+,31-,32+,33-,34+,35-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26459659 | https://www.ncbi.nlm.nih.gov/pubmed/25193007
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/?21479205

Uzarin is a Na(+), K(+)-ATPase inhibitor, a component of Uzara, which has been used for a long time in traditional medicine to treat diarrheal disorders, but the mode of action is not fully known. In Germany, Uzara (Stada, Bad Vilbel, Germany) is frequently used as over-the-counter preparation of the Uzara root, containing 40 mg glycosides/ml.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium/potassium-transporting ATPase 34 Target ID: CHEMBL2095186 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21479205	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diarrhea 36 Sources: https://www.ncbi.nlm.nih.gov/pubmed/?21479205 https://www.ncbi.nlm.nih.gov/pubmed/25193007	Primary		Approved 8583	Uzara Approved Use Diarrhea

PubMed

Title	Date	PubMed
An experimental study on cervix cancer with combination of HSV-TK/GCV suicide gene therapy system and 60Co radiotherapy.	2010-11-06	21054886
Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study.	2010-06-04	20525330

Patents

Sample Use Guides

In Vivo Use Guide

A typical daily dose of uzara may range from 45 to 90 mg of the total glycosides calculated as usarin

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

NSC-407809

Preferred Name

English

UZARIN

Common Name

English

Uzarin [WHO-DD]

Common Name

English

UZARIGENIN 3-.BETA.-SOPHOROSIDE

Common Name

English

CARD-20(22)-ENOLIDE, 3-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-14-HYDROXY-, (3.BETA.,5.ALPHA.)-

Common Name

English

UZARIN [MI]

Common Name

English

Code System Code Type Description

SMS_ID

100000077322