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Details

Stereochemistry ACHIRAL
Molecular Formula C17H13N3O5S2
Molecular Weight 403.432
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHTHALYLSULFATHIAZOLE

SMILES

OC(=O)C1=C(C=CC=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3

InChI

InChIKey=PBMSWVPMRUJMPE-UHFFFAOYSA-N
InChI=1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23)

HIDE SMILES / InChI

Description

Phthalylsulfathiazole is a sulfonamide antibiotic. Phthalylsulfathiazole is an effective remedy in the treatment of dysentery, diarrhea and other intestinal fluxes. It inhibits dihydropteroate synthetase activity of bacteria. In veterinary, it is used for the treatment of diarrhea and enteritis of the calves, dysentery in sheep, gastroenteritis in foals and adult equines, enteritis caused by food poisoning. Phthalylsulfathiazole is only slightly absorbed from the gut, about 5 percent of the quantity ingested being eliminated in the urine. Consequently, it produces little or no systemic effects with virtually no risk of crystalluria, haematuria or oliguria. In hyper-susceptible people, it may cause gastrointestinal side effects, like nausea, vomiting, etc.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Estreptocarbocaftiazol
Curative
Estreptocarbocaftiazol
Curative
Estreptocarbocaftiazol

PubMed

Sample Use Guides

In Vivo Use Guide
1-2 tablets (500-1000 mg), every 4 hours.
Route of Administration: Oral
In Vitro Use Guide
Phthalylsulfathiazole is the best bactericide against E. typhosa, being effective at 1.5 percent, and it is bacteriostatic at 0.5 percent. Against S. paratyphi phthalylsulfathiazole is bactericidal at 2 percent.