FLAVIN ADENINE DINUCLEOTIDE DISODIUM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H31N9O15P2.2Na
Molecular Weight	829.5134
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FLAVIN ADENINE DINUCLEOTIDE DISODIUM

Structure Search

SMILES

[Na+].[Na+].CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)N4C=NC5=C(N)N=CN=C45)C6=NC(=O)NC(=O)C6=NC2=C1

InChI

InChIKey=XLRHXNIVIZZOON-WFUPGROFSA-L

InChI=1S/C27H33N9O15P2.2Na/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;/q;2*+1/p-2/t14-,15+,16+,19-,20+,21+,26+;;/m0../s1

HIDE SMILES / InChI

Description
Sources: http://med.toaeiyo.co.jp/products/flavitantab/pdf/shiorien-flvt10.pdf
Curator's Comment: description was created based on several sources, including: http://www.wikidoc.org/index.php/FAD http://www.drugbank.ca/drugs/DB03147

Flavin adenine dinucleotide is a coenzyme form of vitamin B2. Many oxidoreductases, called flavoenzymes or flavoproteins, require FAD as a prosthetic group, which functions in electron transfers. It is usually used for the prevention and treatment of various diseases that are caused by Vitamin B2 deficiency or metabolic disorder including stomatitis, eczema, etc. No adverse reactions were reported.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
oxidative phosphorylation 5 Target ID: GO:0006119 Sources: https://www.khanacademy.org/science/biology/cellular-respiration-and-fermentation/oxidative-phosphorylation/a/oxidative-phosphorylation-etc	Modulator 828

Conditions

Condition	Modality	Highest Phase	Product
Vitamin B2 deficiency 3 Sources: http://med.toaeiyo.co.jp/products/flavitantab/pdf/shiorien-flvt10.pdf	Palliative	Approved 8429	Flavitan Approved Use It is usually used for the prevention and treatment of various diseases that are caused by Vitamin B2 deficiency Launch Date 1966
Conjunctivitis 17 Sources: http://www.kegg.jp/medicus-bin/japic_med_product?id=00054433 http://med.toaeiyo.co.jp/products/flavitantab/pdf/if-flvt.pdf	Palliative	Approved 8429	Flavitan Approved Use It is an effective in conjunctivitis treatment. Launch Date 1966
Stomatitis 7 Sources: http://med.toaeiyo.co.jp/products/flavitantab/pdf/shiorien-flvt10.pdf	Palliative	Approved 8429	Flavitan Approved Use It is usually used for the prevention and treatment of metabolic disorder including stomatitis. Launch Date 1966

PubMed

Title	Date	PubMed
Flavin adenine dinucleotide concentration in erythrocytes with normal and deficient glucose-6-phosphate dehydrogenase.	1970 Sep 1	5523465
Mechanism of chlorpromazine-induced arrhythmia -- arrhythmia and mitochondrial dysfunction.	1981 Jul	6167651
ACP1GUA-1--a low-activity variant of human erythrocyte acid phosphatase: association with increased glutathione reductase activity.	1982 May	7081221
[Comparison of biochemical criteria for supplying the human body with riboflavin].	1991 Sep-Oct	1759408
Flavin adenine dinucleotide levels in erythrocytes of very low birthweight infants under vitamin supplementation.	1993	8448258
Determination of riboflavin and flavocoenzymes in human blood plasma by high-performance liquid chromatography.	1995	8546438
Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution.	1999 Nov 25	10586875
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.	2000 Feb 15	10666321
Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase.	2001 Mar	11346147
Enzymatic and non-enzymatic reduction of brucine N-oxide by aldehyde oxidase and catalase.	2001 Nov	11765140
Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin.	2011 Apr	21308351

Patents

Sample Use Guides

In Vivo Use Guide

Oral: Take 5 to 45 mg of flavin adenine dinucleotide per day in 1 to 3 divided doses. Injection: 40 mg one or two times per day

Route of Administration: Other

In Vitro Use Guide

The addition of 1uM of FAD was found to exert a consistent activation effect on Glutathione reductase activity.

Name

Type

Language

FLAVIN ADENINE DINUCLEOTIDE DISODIUM

Common Name

English

FLAVIN ADENINE DINUCLEOTIDE SODIUM [JAN]

Common Name

English

DISODIUM FLAVINE ADENINE DINUCLEOTIDE [INCI]

Common Name

English

FAD SODIUM SALT

Common Name

English

FLAVIN ADENINE DINUCLEOTIDE SODIUM SALT

Common Name

English

RIBOFLAVIN 5'-(TRIHYDROGEN DIPHOSPHATE), P'->5'-ESTER WITH ADENOSINE, DISODIUM SALT

Systematic Name

English

DISODIUM FLAVINE ADENINE DINUCLEOTIDE

Official Name

English

Flavine adenine dinucleotide disodium [WHO-DD]

Common Name

English

FLAVINE ADENINE DINUCLEOTIDE DISODIUM

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID0046723