Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C27H31N9O15P2.2Na |
Molecular Weight | 829.5134 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)N4C=NC5=C(N)N=CN=C45)C6=NC(=O)NC(=O)C6=NC2=C1
InChI
InChIKey=XLRHXNIVIZZOON-WFUPGROFSA-L
InChI=1S/C27H33N9O15P2.2Na/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;/q;2*+1/p-2/t14-,15+,16+,19-,20+,21+,26+;;/m0../s1
DescriptionCurator's Comment: description was created based on several sources, including:
http://www.wikidoc.org/index.php/FAD
http://www.drugbank.ca/drugs/DB03147
Curator's Comment: description was created based on several sources, including:
http://www.wikidoc.org/index.php/FAD
http://www.drugbank.ca/drugs/DB03147
Flavin adenine dinucleotide is a coenzyme form of vitamin B2. Many oxidoreductases, called flavoenzymes or flavoproteins, require FAD as a prosthetic group, which functions in electron transfers. It is usually used for the prevention and treatment of various diseases that are caused by Vitamin B2 deficiency or metabolic disorder including stomatitis, eczema, etc. No adverse reactions were reported.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | Flavitan Approved UseIt is usually used for the prevention and treatment of various diseases that are caused by Vitamin B2 deficiency Launch Date1966 |
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Palliative | Flavitan Approved UseIt is an effective in conjunctivitis treatment. Launch Date1966 |
|||
Palliative | Flavitan Approved UseIt is usually used for the prevention and treatment of metabolic disorder including stomatitis. Launch Date1966 |
PubMed
Title | Date | PubMed |
---|---|---|
Flavin adenine dinucleotide concentration in erythrocytes with normal and deficient glucose-6-phosphate dehydrogenase. | 1970 Sep 1 |
|
Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution. | 1999 Nov 25 |
|
Enzymatic and non-enzymatic reduction of brucine N-oxide by aldehyde oxidase and catalase. | 2001 Nov |
Patents
Sample Use Guides
Oral: Take 5 to 45 mg of flavin adenine dinucleotide per day in 1 to 3 divided doses.
Injection: 40 mg one or two times per day
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5822598
The addition of 1uM of FAD was found to exert a consistent activation effect on Glutathione reductase activity.
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ACTIVE MOIETY
SUBSTANCE RECORD