AGANODINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H10Cl2N4
Molecular Weight	245.109
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AGANODINE

Structure Search

SMILES

NC(=N)NN1CC2=C(Cl)C=CC(Cl)=C2C1

InChI

InChIKey=DFKHOVYSCCPSHR-UHFFFAOYSA-N

InChI=1S/C9H10Cl2N4/c10-7-1-2-8(11)6-4-15(3-5(6)7)14-9(12)13/h1-2H,3-4H2,(H4,12,13,14)

HIDE SMILES / InChI

Description
Sources: https://www.researchgate.net/publication/294210987_Potential_mechanisms_involved_in_aganodine-induced_ocular_hypotension

Aganodine, an imidazoline/ alpha-2 receptor agonist, can lower intraocular pressure in the sympathetic neurons of the eye and possibly in the central nervous system.

Approval Year

PubMed

PubMed

Title	Date	PubMed
A search for presynaptic imidazoline receptors at rabbit and rat noradrenergic neurones in the absence of alpha 2-autoinhibition.	1999-02	10048597
Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues.	1997-09	9298527

Name

Type

Language

aganodine [INN]

Preferred Name

English

AGANODINE

Official Name

English

(4,7-DICHLORO-2-ISOINDOLINYL)GUANIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709

Created by admin on Mon Mar 31 18:25:14 GMT 2025 , Edited by admin on Mon Mar 31 18:25:14 GMT 2025

Code System Code Type Description

PUBCHEM

176878

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NCI_THESAURUS

C74229

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EPA CompTox

DTXSID60235775

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ChEMBL

CHEMBL2105912

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EVMPD

SUB05284MIG

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CAS

86696-87-9

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SMS_ID

100000087708

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FDA UNII

670P9AQR46

Created by admin on Mon Mar 31 18:25:14 GMT 2025 , Edited by admin on Mon Mar 31 18:25:14 GMT 2025

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INN

5488

Created by admin on Mon Mar 31 18:25:14 GMT 2025 , Edited by admin on Mon Mar 31 18:25:14 GMT 2025

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WIKIPEDIA

Aganodine

Created by admin on Mon Mar 31 18:25:14 GMT 2025 , Edited by admin on Mon Mar 31 18:25:14 GMT 2025

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ACTIVE MOIETY


					670P9AQR46

AGANODINE