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Details

Stereochemistry RACEMIC
Molecular Formula C18H23N2S
Molecular Weight 299.454
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of THIAZINAMIUM

SMILES

CC(CN1C2=CC=CC=C2SC3=C1C=CC=C3)[N+](C)(C)C

InChI

InChIKey=CDXCCYNINPIWGE-UHFFFAOYSA-N
InChI=1S/C18H23N2S/c1-14(20(2,3)4)13-19-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)19/h5-12,14H,13H2,1-4H3/q+1

HIDE SMILES / InChI
Thiazinamium is an anti-cholinergic phenothiazine deriva¬tive, which also has antihistaminic properties. Intramuscular injection of Thiazinamium induces considerable bronchodilatation, but inconsistent results have been obtained after oral administration. The bioavailability of oral Thiazinamium is only 2-3% of that occurring after intramuscular injection. Intrarectal Thiazinamium is slightly better absorbed (3-9%). The elimination half-life of the parenteral drug is short, being about 20 minutes in most patients. Thiazinamium has been available for the treatment of asthma since the early 1960s but currently withdrawn in most countries. Compared with inhaled ipratropium bromide, intramuscular Thiazinamium and intramuscular atropine were associated with 'extremely frequent side-effects’. Notable tachycardia occurred shortly after intramuscular injection of Thiazinamium in two trials. Dry mouth was reported as ‘frequent’ with oral Thiazinamium, and micturition problems of moderate severity affected 13% of patients.

Approval Year

Name Type Language
THIAZINAMIUM
WHO-DD  
Common Name English
10H-PHENOTHIAZINE-10-ETHANAMINIUM, N,N,N,.ALPHA.-TETRAMETHYL-
Systematic Name English
TRIMETHYL(1-METHYL-2-PHENOTHIAZIN-10-YLETHYL)-AMMONIUM
Systematic Name English
THIAZINAM
Common Name English
Thiazinamium [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
WHO-VATC QR06AD06
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
WHO-ATC R06AD06
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID00102163
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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DRUG BANK
DB13420
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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EVMPD
SUB15532MIG
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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ECHA (EC/EINECS)
219-051-7
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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PUBCHEM
6016
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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FDA UNII
666W2P28N2
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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MESH
C084594
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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SMS_ID
100000076995
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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CAS
2338-21-8
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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WIKIPEDIA
Thiazinamium
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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DRUG CENTRAL
2628
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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NCI_THESAURUS
C84203
Created by admin on Fri Dec 15 16:29:30 GMT 2023 , Edited by admin on Fri Dec 15 16:29:30 GMT 2023
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