FLUOCORTOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29FO4
Molecular Weight	376.4617
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=GAKMQHDJQHZUTJ-ULHLPKEOSA-N

InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12650700 | https://www.ncbi.nlm.nih.gov/pubmed/3743619
Curator's Comment: description was created based on several sources, including http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1

Fluocortolone is a topical corticosteroid (class of steroid hormones formed in the adrenal gland). Is primary indicated in condition like, Ana fissure, Dermatosis haemorrhoids, proctitis. The signs and symptoms that are produced after the acute overdosage include convulsions, respiratory arrest, allergic skin reactions. Glucocorticoids, such as fluocortolone, act through nuclear hormone receptors Schaaf and Cidlowski (2002). The two members of this family are glucocorticoid receptor (GR) type I and GR type I I. Activation of these sites alters gene expression of endogenous agents that influence immune and inflammatory responses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12650700	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Anal fissure 6 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown
Haemorrhoids 6 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown
Proctitis 4 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Contact allergies to topical corticosteroids: 10 cases of contact dermatitis.	1991 Aug	1834432
Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial.	2001 Apr	11297592
Systemic mycophenolate mofetil in comparison with systemic cyclosporin A in high-risk keratoplasty patients: 3 years' results of a randomized prospective clinical trial.	2001 Jun	11482341
Adalimumab for the treatment of fistulas in patients with Crohn's disease.	2009 Jul	19201775
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.	2010 Apr	20155493
A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves' orbitopathy.	2010 Jan	19865824

Patents

Sample Use Guides

In Vivo Use Guide

adult: 0.025 %; Frequency: 8 hours

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

FLUOCORTOLONE

Official Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,21-DIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

Fluocortolone [WHO-DD]

Common Name

English

FLUOCORTOLONE [MART.]

Common Name

English

FLUOCORTOLONE [MI]

Common Name

English

fluocortolone [INN]

Common Name

English

FLUOCORTOLONE [USAN]

Common Name

English

SH 742

Code

English

6α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Systematic Name

English

FLUOCORTOLONE [JAN]

Common Name

English

SH-742

Code

English

Classification Tree Code System Code

WHO-VATC

QH02AB03