OLODATEROL HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H26N2O5.ClH
Molecular Weight	422.902
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC=C(CC(C)(C)NC[C@H](O)C2=CC(O)=CC3=C2OCC(=O)N3)C=C1

InChI

InChIKey=KCEHVJZZIGJAAW-FERBBOLQSA-N

InChI=1S/C21H26N2O5.ClH/c1-21(2,10-13-4-6-15(27-3)7-5-13)22-11-18(25)16-8-14(24)9-17-20(16)28-12-19(26)23-17;/h4-9,18,22,24-25H,10-12H2,1-3H3,(H,23,26);1H/t18-;/m0./s1

HIDE SMILES / InChI

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf
Curator's Comment: description was created based on several sources, including http://www.drugdevelopment-technology.com/projects/striverdi-respimat-for-the-maintenance-treatment-of-copd/; http://www.ncbi.nlm.nih.gov/pubmed/?term=20371707

Olodaterol is a beta2-adrenoceptor agonist discovered by Boehringer Ingelheim and approved for the treatment of Chronic Obstructive Pulmonary Disease. The compound exerts its pharmacological effects by binding and activation of beta2-adrenoceptors after inhalation. Activation of these receptors in the airways results in a stimulation of intracellular adenyl cyclase, an enzyme that mediates the synthesis of cyclic-3’, 5’ adenosine monophosphate (cAMP). Elevated levels of cAMP induce bronchodilation by relaxation of airway smooth muscle cells. Olodaterol effect lasts for 24 hours.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-2 adrenergic receptor 203 Target ID: P07550\|\|\|Q53GA6\|\|\|Q9UCZ3 Gene ID: 154.0 Gene Symbol: ADRB2 Target Organism: Homo sapiens (Human) Sources: http://www.ncbi.nlm.nih.gov/pubmed/?term=20371707	Agonist 2678		0.1 nM [EC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic obstructive pulmonary disease 174 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf	Primary		Approved 8429	STRIVERDI RESPIMAT Approved Use The long-term, once-daily maintenance bronchodilator treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Is not indicated to treat acute deterioration of COPD and asthma. Launch Date 2014

C_max

Value	Dose	Co-administered	Analyte	Population
5.92 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26316741	5 μg 1 times / day multiple, respiratory dose: 5 μg route of administration: Respiratory experiment type: MULTIPLE co-administered:		OLODATEROL HYDROCHLORIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
13.1 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26316741	10 μg 1 times / day multiple, respiratory dose: 10 μg route of administration: Respiratory experiment type: MULTIPLE co-administered:		OLODATEROL HYDROCHLORIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
104 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26316741	5 μg 1 times / day multiple, respiratory dose: 5 μg route of administration: Respiratory experiment type: MULTIPLE co-administered:		OLODATEROL HYDROCHLORIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
160 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/26316741	10 μg 1 times / day multiple, respiratory dose: 10 μg route of administration: Respiratory experiment type: MULTIPLE co-administered:		OLODATEROL HYDROCHLORIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
7.5 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/203108s008lbl.pdf	5 μg 1 times / day unknown, unknown dose: 5 μg route of administration: UNKNOWN experiment type: UNKNOWN co-administered:		OLODATEROL HYDROCHLORIDE plasma	Homo sapiens population: UNHEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
40% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/203108s008lbl.pdf	5 μg 1 times / day unknown, unknown dose: 5 μg route of administration: UNKNOWN experiment type: UNKNOWN co-administered:		OLODATEROL HYDROCHLORIDE plasma	Homo sapiens population: UNHEALTHY age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737 inhibitor 1587 inducer 781	substrate 1037 inhibitor 1767 inducer 389	inhibitor 1852	inhibitor 1612

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1461 BCRP 699 CYP1A1 110 CYP1A2 1524 CYP2A6 707 CYP2B6 810 CYP2C8 911 CYP2C19 1478 CYP2E1 882 CYP4A11 21	CYP2C8 693 UGT2B7 389 UGT1A1 418 UGT1A7 236 UGT1A9 380 P-gp 1537	CYP1A2 701 CYP2B6 547 CYP2C8 168 CYP2C19 293

Drug as perpetrator

Target	Modality	Activity
CYP1A1 218	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP1A2 1692	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP2A6 739	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP2B6 1001	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP2C19 1553	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP2C8 965	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP2C9 1819	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP2E1 970	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP3A4 1925	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP4A11 25	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no [IC50 >100 uM]
CYP1A2 1692	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no
CYP2B6 1001	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no
CYP2C19 1553	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no
CYP2C8 965	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no
CYP2C9 1819	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no
CYP3A4 1925	inducer 1573 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	no
BCRP 773	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=25 Page: 25.0	weak [IC50 100 uM]
P-gp 1650	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=25 Page: 25.0	weak [IC50 365 uM]
CYP2D6 1891	inhibitor 3277 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=26 Page: 26.0	yes [Ki 1.92 uM]

Drug as victim

Target	Modality	Activity	Clinical evidence
CYP3A4 1737	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	minor	yes (co-administration study) Comment: Ketoconazole: Co-administration of 400 mg ketoconazole once a day for 14 days increased olodaterol Cmax by 66% and AUC0-1 by 68%. Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0
CYP2C9 1037	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	weak	no (co-administration study) Comment: Co-administration of 400 mg fluconazole once a day for 14 days had no relevant effect on systemic exposure to olodaterol. Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0
CYP2C8 693	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	yes
P-gp 1537	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000ClinPharmR.pdf#page=3 Page: 3.0	yes
UGT1A1 418	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	yes
UGT1A7 236	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	yes
UGT1A9 380	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	yes
UGT2B7 389	substrate 3367 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203108s000lbl.pdf#page=8 Page: 8.0	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 1647	inhibitor 1626 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203108Orig1s000PharmR.pdf#page=54 Page: 54.0

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:82700	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:82700
ChemicalBook	CB52484977	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB52484977
MolPort	MolPort-044-183-629	https://www.molport.com/shop/molecule-link/MolPort-044-183-629
ZINC	ZINC000034636383	http://zinc15.docking.org/substances/ZINC000034636383

PubMed

Title	Date	PubMed
Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy.	2010 Feb 15	20096576
Lung function efficacy and symptomatic benefit of olodaterol once daily delivered via Respimat® versus placebo and formoterol twice daily in patients with GOLD 2-4 COPD: results from two replicate 48-week studies.	2014	25045258

Patents

Sample Use Guides

In Vivo Use Guide

Two inhalations of STRIVERDI RESPIMAT once-daily at the same time of day. Inhalation spray: Each actuation from the mouthpiece contains 2.7 mcg olodaterol hydrochloride, equivalent to 2.5 mcg olodaterol. Two actuations equal one dose.

Route of Administration: Respiratory

In Vitro Use Guide

MRC-5 human lung fibroblasts were cultured in absence or presence of 10 nM olodaterol, followed by ß2-adrenoceptor mRNA determination by quantitative real time PCR

Name

Type

Language

OLODATEROL HYDROCHLORIDE

Official Name

English

OLODATEROL HYDROCHLORIDE [VANDF]

Common Name

English

OLODATEROL HYDROCHLORIDE [MI]

Common Name

English

6-HYDROXY-8-((1R)-1-HYDROXY-2-((2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYL)AMINO)ETHYL)- 2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE

Systematic Name

English

6-Hydroxy-8-[(1R)-1-hydroxy-2-{[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino}ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride

Systematic Name

English

BI 1744 CL

Code

English

STRIVERDI RESPIMAT

Brand Name

English

2H-1,4-BENZOXAZIN-3(4H)-ONE, 6-HYDROXY-8-((1R)-1-HYDROXY-2-((2-(4-METHOXYPHENYL)- 1,1-DIMETHYLETHYL)AMINO)ETHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

BI-1744-CL

Code

English

OLODATEROL HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

Olodaterol hydrochloride [WHO-DD]

Common Name

English

OLODATEROL HYDROCHLORIDE [USAN]

Common Name

English

BI-1744 CL

Code

English

Code System Code Type Description

PUBCHEM

11711522

Created by admin on Fri Dec 15 16:05:09 GMT 2023 , Edited by admin on Fri Dec 15 16:05:09 GMT 2023

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FDA UNII

65R445W3V9

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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CHEBI

83309

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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DAILYMED

65R445W3V9

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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EVMPD

SUB131075

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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CAS

869477-96-3

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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MERCK INDEX

m11957

Created by admin on Fri Dec 15 16:05:09 GMT 2023 , Edited by admin on Fri Dec 15 16:05:09 GMT 2023

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USAN

YY-81

Created by admin on Fri Dec 15 16:05:09 GMT 2023 , Edited by admin on Fri Dec 15 16:05:09 GMT 2023

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DRUG BANK

DBSALT001112

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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ChEMBL

CHEMBL605846

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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SMS_ID

100000156938

Created by admin on Fri Dec 15 16:05:09 GMT 2023 , Edited by admin on Fri Dec 15 16:05:09 GMT 2023

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NCI_THESAURUS

C166904

Created by admin on Fri Dec 15 16:05:09 GMT 2023 , Edited by admin on Fri Dec 15 16:05:09 GMT 2023

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EPA CompTox

DTXSID901027733

Created by admin on Fri Dec 15 16:05:08 GMT 2023 , Edited by admin on Fri Dec 15 16:05:08 GMT 2023

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RXCUI

1546396

Created by admin on Fri Dec 15 16:05:09 GMT 2023 , Edited by admin on Fri Dec 15 16:05:09 GMT 2023

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RxNorm

ACTIVE MOIETY


					VD2YSN1AFD

OLODATEROL

SUBSTANCE RECORD


					65R445W3V9

OLODATEROL HYDROCHLORIDE

Details

SMILES

InChI

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Cmax

AUC

T1/2

Funbound

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Tox targets

Sourcing

PubMed

Patents

Sample Use Guides

C_max

T_1/2

F_unbound

Drug as perpetrator