Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H27ClN4O3 |
| Molecular Weight | 430.928 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C(=O)CNC(=O)[C@@H](N)CCCCN)C1=CC=C(Cl)C=C1C(=O)C2=CC=CC=C2
InChI
InChIKey=LTKOVYBBGBGKTA-SFHVURJKSA-N
InChI=1S/C22H27ClN4O3/c1-27(20(28)14-26-22(30)18(25)9-5-6-12-24)19-11-10-16(23)13-17(19)21(29)15-7-3-2-4-8-15/h2-4,7-8,10-11,13,18H,5-6,9,12,14,24-25H2,1H3,(H,26,30)/t18-/m0/s1
Avizafone is a water-soluble peptide prodrug of diazepam that is hydrolyzed by an aminopeptidase to liberate lysine and diazepam Avizafone was developed by the French military to terminate seizures caused by battlefield nerve agents. Diazepam has a faster entry to the general circulation and achieved higher maximum concentration after injection of prodrug than after the parent drug and this is extremely valuable in nerve agents poisoning conditions.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig. | 2006 Aug 1 |
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| Pyridinium oximes: rationale for their selection as causal antidotes against organophosphate poisonings and current solutions for auto-injectors. | 2006 Dec |
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| Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. | 2006 Feb |
|
| LC-UV and LC-MS evaluation of stress degradation behaviour of avizafone. | 2006 Jun 16 |
|
| Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig. | 2016 Feb 26 |
Patents
| Name | Type | Language | ||
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Code | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C28197
Created by
admin on Fri Dec 15 15:40:15 GMT 2023 , Edited by admin on Fri Dec 15 15:40:15 GMT 2023
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NCI_THESAURUS |
C29756
Created by
admin on Fri Dec 15 15:40:15 GMT 2023 , Edited by admin on Fri Dec 15 15:40:15 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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65NK71K78P
Created by
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PRIMARY | |||
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SUB05616MIG
Created by
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CHEMBL2103985
Created by
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PRIMARY | |||
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C065249
Created by
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PRIMARY | |||
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71968
Created by
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PRIMARY | |||
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DTXSID90215868
Created by
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PRIMARY | |||
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100000086642
Created by
admin on Fri Dec 15 15:40:15 GMT 2023 , Edited by admin on Fri Dec 15 15:40:15 GMT 2023
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PRIMARY | |||
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AVIZAFONE
Created by
admin on Fri Dec 15 15:40:15 GMT 2023 , Edited by admin on Fri Dec 15 15:40:15 GMT 2023
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PRIMARY | |||
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65617-86-9
Created by
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6723
Created by
admin on Fri Dec 15 15:40:15 GMT 2023 , Edited by admin on Fri Dec 15 15:40:15 GMT 2023
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C72708
Created by
admin on Fri Dec 15 15:40:15 GMT 2023 , Edited by admin on Fri Dec 15 15:40:15 GMT 2023
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PRIMARY |
METABOLITE ACTIVE (PRODRUG)
SUBSTANCE RECORD
