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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H17ClN3O5S.Na.H2O
Molecular Weight 475.878
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOXACILLIN SODIUM

SMILES

O.[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C3=C(C)ON=C3C4=CC=CC=C4Cl)C([O-])=O

InChI

InChIKey=KCUWTKOTPIUBRI-VICXVTCVSA-M
InChI=1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

HIDE SMILES / InChI

Description

Cloxacillin is a derivative of penicillin for the treatment of broad spectrum of bacterial infections. The drug exerts its action by inhiiting bacterial beta-lactamase (penicillin-binding proteins).

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN
Curative
TEGOPEN

Cmax

ValueDoseCo-administeredAnalytePopulation
60 μg/mL
2 g single, intravenous
CLOXACILLIN serum
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
310 μg × h/mL
2 g single, intravenous
CLOXACILLIN serum
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
43 min
2 g single, intravenous
CLOXACILLIN serum
Homo sapiens

Doses

AEs

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer








Drug as perpetrator​

Drug as victim

PubMed

Sample Use Guides

In Vivo Use Guide
Recommended dose for adults is 500 mg four times a day, one for 2-10 y.o. Kids is 250 mg four times a day, children younger than 2 y.o. should take 125 mg of Tegopen four times a day.
Route of Administration: Oral
In Vitro Use Guide
The MIC of the cloxacillin for 5 MRSA (methicillin-resistant S.Aureus) strains were more than 32 (ug/ml), for 1 MRSA strain was more than 128(ug/ml) and for another 4 MRSA strains were above was more than 128 (ug/ml).