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Details

Stereochemistry ABSOLUTE
Molecular Formula C29H44O9
Molecular Weight 536.6543
Optical Activity UNSPECIFIED
Defined Stereocenters 13 / 13
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUCODIGITOXIGENIN

SMILES

C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](CC[C@]34C)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@]1(O)CC[C@@H]2C6=CC(=O)OC6

InChI

InChIKey=CMHWMOGWFZWDMR-FVGBAMMESA-N
InChI=1S/C29H44O9/c1-27-8-5-17(37-26-25(34)24(33)23(32)21(13-30)38-26)12-16(27)3-4-20-19(27)6-9-28(2)18(7-10-29(20,28)35)15-11-22(31)36-14-15/h11,16-21,23-26,30,32-35H,3-10,12-14H2,1-2H3/t16-,17+,18-,19+,20-,21-,23-,24+,25-,26-,27+,28-,29+/m1/s1

HIDE SMILES / InChI

Description

Cardiotonic agent. Glucodigitoxigenin (digitoxigenin-glucoside) is a constituent of the cardenolide complex. Glucodigitoxigenin (0.056 umol/kg) produced increases in myocardial contractility. Glucodigitoxigenin caused a significantly greater increase in blood pressure than digoxin.

Originator

Elderfield, R.C. et al.
1

Approval Year

Unknown
149,124

Targets

Primary TargetPharmacologyConditionPotency
cardiac muscle contraction
1
Activator
1,447

Conditions

ConditionModalityTargetsHighest PhaseProduct
Heart Failure
7
 Primary
Basic research
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Dogs: 0.056 umol/kg
Route of Administration: Unknown
In Vitro Use Guide
Unknown
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