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Details

Stereochemistry RACEMIC
Molecular Formula C19H22N2O
Molecular Weight 294.3908
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VINBURNINE, (±)-

SMILES

[H][C@]12N3CCC[C@@]1(CC)CC(=O)N4C5=CC=CC=C5C(CC3)=C24

InChI

InChIKey=WYJAPUKIYAZSEM-MOPGFXCFSA-N
InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1

HIDE SMILES / InChI

Description

Vinburnine is a nutritional product, which is semi-synthesized from vincamine. It is a peripheral vasodilator with cerebral activities that also act as a cerebral metabolic stimulant and appears to be able to relax the smooth muscle cells within the walls of blood vessels. Some evidence also suggests that vinburnine stimulates acetylcholine neurotransmission. Acetylcholine is a very important neurotransmitter responsible for a number of cognitive functions, such as memory and learning.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
68.9 µM [Kd]
7.54 µM [Kd]
6.67 µM [Kd]
23.7 µM [Kd]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CERVOXAN

PubMed

Sample Use Guides

In Vivo Use Guide
The recommended dosage is 60 mg taken twice a day.
Route of Administration: Oral
In Vitro Use Guide
Different concentrations of the three drugs, vincamine, vinpocetine, and eburnamonine, (4, 20 and 100 uM) induced minimal stimulation of the ATPase activity of the Bcrp and Pgp membrane transporters.