U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H23NO3.ClH
Molecular Weight 349.852
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXYFEDRINE HYDROCHLORIDE

SMILES

Cl.COC1=CC=CC(=C1)C(=O)CCN[C@@H](C)[C@H](O)C2=CC=CC=C2

InChI

InChIKey=JMUPNNYLJGSMPK-JPJJPTBZSA-N
InChI=1S/C19H23NO3.ClH/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2;/h3-10,13-14,19-20,22H,11-12H2,1-2H3;1H/t14-,19-;/m0./s1

HIDE SMILES / InChI
Oxyfedrine, an amino ketone derivative and partial agonist at beta receptors, has been shown to have potent antianginal properties and to increase coronary blood flow in normal and ischemic myocardial regions.

Approval Year

PubMed

PubMed

TitleDatePubMed
[The management of angina pectoris using Ildamen, a new coronary- and cardiac-active substance, in a double-blind study].
1967 Sep 10
[Stimulation of adrenergic beta-receptors in the heart of normal and reserpinized guinea pigs by oxyfedrine].
1969 Sep
Pulmonary and systemic circulatory effects and -adrenergic selectivity of hexoprenaline, salbutamol, oxyfedrine, and isoproterenol.
1971 Jul
Effects of oxyfedrine on regional myocardial blood flow in patients with coronary artery disease.
1991 Dec
Patents

Sample Use Guides

Oral Myocardial infarction, Angina pectoris Adult: 8-24 mg tid.
Route of Administration: Oral
Oxyfedrine was tested in vitro against 471 strains of bacteria from two Gram positive and fourteen Gram negative genera. The minimum inhibitory concentration (MIC) of oxyfedrine was determined by agar dilution method, which ranged from 50-200 ug/ml in most of the strains, while some strains were inhibited at even lower concentrations.
Name Type Language
OXYFEDRINE HYDROCHLORIDE
JAN   MART.   WHO-DD  
Common Name English
3-(((.ALPHA.S,.BETA.R)-.BETA.-HYDROXY-.ALPHA.-METHYLPHENETHYL)AMINO)-3'-METHOXYPROPIOPHENONE HYDROCHLORIDE
Common Name English
Oxyfedrine hydrochloride [WHO-DD]
Common Name English
OXYFEDRINE HYDROCHLORIDE [MART.]
Common Name English
L-OXYFEDRINE HYDROCHLORIDE
Common Name English
OXYFEDRINE HYDROCHLORIDE [JAN]
Common Name English
FDA-1576
Code English
1-PROPANONE, 3-(((1S,2R)-2-HYDROXY-1-METHYL-2-PHENYLETHYL)AMINO)-1-(3-METHOXYPHENYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
ILDAMEN
Brand Name English
D-563
Code English
MODACOR
Brand Name English
OXYFEDRINE HCL
Common Name English
OXYFEDRINE L-FORM HYDROCHLORIDE [MI]
Common Name English
OXYFEDRINE L-FORM HYDROCHLORIDE
MI  
Common Name English
PROPIOPHENONE, 3-((.BETA.-HYDROXY-.ALPHA.-METHYLPHENETHYL)AMINO)-3'-METHOXY-, HYDROCHLORIDE, (-)-
Systematic Name English
OXYFEDRINE HYDROCHLORIDE, (-)-
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29707
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
NCI_THESAURUS C48149
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C77154
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
EPA CompTox
DTXSID0048632
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
FDA UNII
63CF9XK7DA
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
ChEMBL
CHEMBL1651913
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
SMS_ID
100000085492
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
PUBCHEM
5489012
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
RXCUI
236758
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
240-696-5
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
CAS
16648-69-4
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
EVMPD
SUB03586MIG
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
CAS
16777-42-7
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY
MERCK INDEX
m8331
Created by admin on Fri Dec 15 16:27:53 GMT 2023 , Edited by admin on Fri Dec 15 16:27:53 GMT 2023
PRIMARY Merck Index