Details
| Stereochemistry | MIXED |
| Molecular Formula | C34H38N4O6.ClH.H2O |
| Molecular Weight | 653.165 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Cl.CC(O)C1=C(C)C2=CC3=C(C(C)O)C(C)=C(N3)C=C4N=C(C=C5NC(=CC1=N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C
InChI
InChIKey=DJUQXKVMJTWUCD-UDHHKLSBSA-N
InChI=1S/C34H38N4O6.ClH.H2O/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27;;/h11-14,19-20,36-37,39-40H,7-10H2,1-6H3,(H,41,42)(H,43,44);1H;1H2/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-;;
Hematoporphyrin (Photodyn), a porphyrin prepared from hemin, is used as a photosensitizer in photodynamic therapy. Photodynamic therapy is based on the use of light-sensitive photosensitizers. Photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death. Hematoporphyrin was used as the therapeutic agent in patients with manic-depressive reactions and in patients with involutional melancholia. One of the last studies has shown, that Hematoporphyrin-Photodynamic therapy (PDT) combined with stent placement is an effective and safe treatment for extrahepatic cholangiocarcinoma (EHCC).
Approval Year
Sample Use Guides
Twenty-three patients with manic-depressive reactions were treated during the depressed phase with intramuscular and oral administration of hematoporphyrin hydrochloride for an average period of 50 to 6o days. Of this number five showed marked sustained improvement, six showed moderate sustained improvement, and six were generally benefited but the course of the psychosis did not seem to be positively affected. Six gave no favorable response. Seventeen patients of 23 can be said to have been definitely helped by the treatment
Route of Administration:
Other
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
63BCJ5R11D
Created by
admin on Sat Dec 16 10:48:41 GMT 2023 , Edited by admin on Sat Dec 16 10:48:41 GMT 2023
|
PRIMARY | |||
|
DTXSID10362202
Created by
admin on Sat Dec 16 10:48:41 GMT 2023 , Edited by admin on Sat Dec 16 10:48:41 GMT 2023
|
PRIMARY | |||
|
6033-08-5
Created by
admin on Sat Dec 16 10:48:41 GMT 2023 , Edited by admin on Sat Dec 16 10:48:41 GMT 2023
|
PRIMARY | |||
|
m5941
Created by
admin on Sat Dec 16 10:48:41 GMT 2023 , Edited by admin on Sat Dec 16 10:48:41 GMT 2023
|
PRIMARY | Merck Index |
SUBSTANCE RECORD
