Details
| Stereochemistry | MIXED |
| Molecular Formula | C34H38N4O6.ClH.H2O |
| Molecular Weight | 653.165 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Cl.CC(O)C1=C(C)C2=CC3=C(C(C)O)C(C)=C(N3)C=C4N=C(C=C5NC(=CC1=N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C
InChI
InChIKey=DJUQXKVMJTWUCD-UDHHKLSBSA-N
InChI=1S/C34H38N4O6.ClH.H2O/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27;;/h11-14,19-20,36-37,39-40H,7-10H2,1-6H3,(H,41,42)(H,43,44);1H;1H2/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-;;
Hematoporphyrin (Photodyn), a porphyrin prepared from hemin, is used as a photosensitizer in photodynamic therapy. Photodynamic therapy is based on the use of light-sensitive photosensitizers. Photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death. Hematoporphyrin was used as the therapeutic agent in patients with manic-depressive reactions and in patients with involutional melancholia. One of the last studies has shown, that Hematoporphyrin-Photodynamic therapy (PDT) combined with stent placement is an effective and safe treatment for extrahepatic cholangiocarcinoma (EHCC).
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Detection and localization of In situ carcinoma of the bladder with hematoporphyrin derivative. | 1982 Sep |
|
| The use of hematoporphyrin derivative (HpD) in the localization and treatment of transitional cell carcinoma (TCC) of the bladder. | 1984 |
|
| Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency. | 1990 |
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| [Effects of quercetin on photosensitized oxidation of alpha-tocopherol in human blood cells in the presence of hematoporphyrin]. | 1990 |
|
| Separation of lipoproteins, albumin and gamma-globulin by single-step ultracentrifugation of human serum. Application. I: Binding of hematoporphyrin to human serum and to albumin. | 1995 Apr |
|
| Temperature-induced changes in fluorescence properties as a probe of porphyrin microenvironment in lipid membranes. 2. The partition of hematoporphyrin and protoporphyrin in mitochondria. | 1995 Oct 1 |
|
| Structural investigation of the complexation properties between horse spleen apoferritin and metalloporphyrins. | 1996 Mar |
|
| Low-density lipoprotein receptors in the uptake of tumour photosensitizers by human and rat transformed fibroblasts. | 2002 Jan |
|
| Photodynamic therapy: a new approach to prostate cancer. | 2003 Jun |
|
| YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX. | 2006 Mar |
|
| Interaction of porphyrins with human organic anion transporting polypeptide 1B1. | 2009 Nov 10 |
|
| Mitochondrial reactive oxygen species accelerate the expression of heme carrier protein 1 and enhance photodynamic cancer therapy effect. | 2014 Jul |
Sample Use Guides
Twenty-three patients with manic-depressive reactions were treated during the depressed phase with intramuscular and oral administration of hematoporphyrin hydrochloride for an average period of 50 to 6o days. Of this number five showed marked sustained improvement, six showed moderate sustained improvement, and six were generally benefited but the course of the psychosis did not seem to be positively affected. Six gave no favorable response. Seventeen patients of 23 can be said to have been definitely helped by the treatment
Route of Administration:
Other
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63BCJ5R11D
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DTXSID10362202
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6033-08-5
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m5941
Created by
admin on Sat Dec 16 10:48:41 GMT 2023 , Edited by admin on Sat Dec 16 10:48:41 GMT 2023
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PRIMARY | Merck Index |
SUBSTANCE RECORD
