VERRUCARIN J

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H32O8
Molecular Weight	484.5382
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)C=C\C=C\C(=O)OCC\C(C)=C\C(=O)OC[C@@]2(CC1)[C@]4(C)[C@]35CO5

InChI

InChIKey=GXCGYHWSYNQVHU-GYDJLPFWSA-N

InChI=1S/C27H32O8/c1-17-8-10-26-15-32-24(30)13-18(2)9-11-31-22(28)6-4-5-7-23(29)35-19-14-21(34-20(26)12-17)27(16-33-27)25(19,26)3/h4-7,12-13,19-21H,8-11,14-16H2,1-3H3/b6-4+,7-5-,18-13+/t19-,20-,21-,25-,26-,27+/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.freepatentsonline.com/article/Texas-Journal-Science/81138291.html | https://www.ncbi.nlm.nih.gov/pubmed/11277768

One of the most important trichothecene, verrucarin J produced by several genera of fungi that may contaminate foods of both human and animal. Verrucarin J has shown cytotoxic activity in human HL-60 cell line and murine L1210 cell line.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Candida albicans 14 Target ID: CHEMBL366 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26320597	Inhibitor 8504
HL-60 8 Target ID: CHEMBL383 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11277768	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Candida albicans infection 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26320597	Curative		Basic research	Unknown Approved Use Unknown
Acute myeloid leukemia 141 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11277768	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Macrocyclic trichothecenes are undetectable in kudzu (Pueraria montana) plants treated with a high-producing isolate of Myrothecium verrucaria.	2001-09	11551550
A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau.	2001-03	11277768

Patents

Sample Use Guides

In Vivo Use Guide

Two sublethal doses of verrucarin J (0.9 and 0.5 mg/kg body weight) extracted from rice seeds were injected intraperitoneally to male mice for two, four, six and eight weeks (for each dose) and were compared with control groups.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Verrucarin J inhibited HL-60 cells with IC50 2.5 ng/mL

Name

Type

Language

VERRUCARIN J

Common Name

English

MUCONOMYCIN B

Preferred Name

English

VERRUCARIN A, 2',3'-DIDEHYDRO-2'-DEOXY-, (2'E)-

Common Name

English

VERRUCARIN J [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m11430