Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H4N4O6 |
| Molecular Weight | 252.1406 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+](=O)C1=CC2=C(NC(=O)C(=O)N2)C=C1[N+]([O-])=O
InChI
InChIKey=RWVIMCIPOAXUDG-UHFFFAOYSA-N
InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
FG-9041 (6,7-Dinitroquinoxaline-2,3-dion or DNQX) is an antagonist of non-NMDA glutamate (AMPA and kainate) receptor. FG-9041 is used in molecular biology to identify the properties of different types of channels. In addition, experiments in rats have shown that DNQX reduces electroconvulsive shock-induced impairment of learning-memory.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Methotrexate induces seizure and decreases glutamate uptake in brain slices: prevention by ionotropic glutamate receptors antagonists and adenosine. | 2006 Dec 3 |
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| NMDA receptor/L-VGCC-dependent expression and AMPA/KA receptor-dependent activation of c-Jun induced by cerebral ischemia in rat hippocampus. | 2006 May 8 |
|
| Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release. | 2007 Dec |
|
| AMPA and NMDA receptor regulation of firing activity in 5-HT neurons of the dorsal and median raphe nuclei. | 2007 May |
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| Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex. | 2008 Apr 2 |
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| Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens. | 2008 Jul 9 |
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| Efficient network reconstruction from dynamical cascades identifies small-world topology of neuronal avalanches. | 2009 Jan |
|
| Icilin-induced wet-dog shakes in rats are dependent on NMDA receptor activation and nitric oxide production. | 2009 May |
Patents
Sample Use Guides
Forty-eight adult Wistar-Kyoto (WKY) rats (an animal model for depressive behavior): DNQX (FG9041) (iv 2 mL 5 mg/kg DNQX through the tail veins of WKY rats )
Route of Administration:
Intravenous
It was tested the effects of the quinoxaline derivative DNQX (FG9041) on the membrane potential of thalamic reticular nucleus (TRN) and ventrobasal (VB) neurons. DNQX (20 μM) produced a slow-onset, long-duration depolarization in all TRN neurons tested with average amplitude of 3.3 ± 1.1 mV. In contrast, DNQX (20 μM) did not alter the membrane potential (0.2 ± 0.5 mV, n = 6) or input resistance of VB neurons. Accordingly, in voltage-clamp recordings, DNQX (20 μM) evoked an inward current that averaged −14.3 ± 5.6 pA but not in VB neurons (1.3 ± 2.3 pA, n = 5, P > 0.1). At a lower concentration, DNQX (4 μM) produced a negligible depolarization (0.3 ± 0.3 mV, n = 5) in TRN neurons, but at higher concentrations, DNQX (100 μM) produced a larger depolarization that averaged 3.7 ± 1.6 mV.
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3899541
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62T278S1MX
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2379-57-9
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DTXSID60178476
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DB03759
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DNQX
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ACTIVE MOIETY
