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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H25N
Molecular Weight 255.3978
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMEMORFAN

SMILES

[H][C@]12CCCC[C@]13CCN(C)[C@H]2CC4=CC=C(C)C=C34

InChI

InChIKey=KBEZZLAAKIIPFK-NJAFHUGGSA-N
InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1

HIDE SMILES / InChI

Description

Dimemorfan is a nonnarcotic antitussive drug. The antitussive action of dimemorfan appears to be directly on the cough center in the medulla.

CNS Activity

CNS Active
3913
Curator's Comment: Dimemorfan exhibits an anticonvulsant effect.

Originator

Yamanouchi Pharmaceutical
31
Curator's Comment: Yamanouchi Pharmaceutical now is a part of Astellas Pharma.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
ASTOMIN

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effect of the centrally acting antitussives on ascites tumor cells.
1983 Apr
The nonnarcotic antitussive drug dimemorfan: a review.
1997 Mar-Apr
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes.
2005 Jul 1
[Otorhinolaringologyc approach of the chronic cough. Clinical case].
2007
The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes.
2010 Feb
Patents

Patents

JP2001097856A
2
JP2001151677A
2
JP2005289904A
2
JP2005289905A
2
JP2005289906A
2
JPH1072349A
2

Sample Use Guides

In Vivo Use Guide
20 mg three times daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
DIMEMORFAN
INN   MI   WHO-DD  
INN  
Official Name English
DIMEMORFAN [MI]
Common Name English
dimemorfan [INN]
Common Name English
Dimemorfan [WHO-DD]
Common Name English
(+)-3,17-DIMETHYLMORPHINAN
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C66917
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
WHO-VATC QR05DA11
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
WHO-ATC R05DA11
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
NCI_THESAURUS C264
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
Code System Code Type Description
MESH
C012621
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
WIKIPEDIA
Dimemorfan
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PRIMARY
ChEMBL
CHEMBL2106325
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PRIMARY
MERCK INDEX
m4499
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PRIMARY Merck Index
EVMPD
SUB07158MIG
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PRIMARY
SMS_ID
100000082655
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PRIMARY
DRUG BANK
DB13810
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PRIMARY
CAS
36309-01-0
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PRIMARY
FDA UNII
623OAC38YU
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PRIMARY
PUBCHEM
3037918
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
EPA CompTox
DTXSID301043335
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
NCI_THESAURUS
C65399
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
INN
3497
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
DRUG CENTRAL
900
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
252-963-3
Created by admin on Fri Dec 15 16:05:56 GMT 2023 , Edited by admin on Fri Dec 15 16:05:56 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of DIMEMORFAN
SALT/SOLVATE (PARENT)
Structure of DIMEMORFAN PHOSPHATE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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