Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C18H25N |
Molecular Weight | 255.3978 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CCCC[C@]13CCN(C)[C@H]2CC4=CC=C(C)C=C34
InChI
InChIKey=KBEZZLAAKIIPFK-NJAFHUGGSA-N
InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/9152562
Sources: http://www.ncbi.nlm.nih.gov/pubmed/9152562
Dimemorfan is a nonnarcotic antitussive drug. The antitussive action of dimemorfan appears to be directly on the cough center in the medulla.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sources: http://www.ncbi.nlm.nih.gov/pubmed/9152562 |
Curative | ASTOMIN Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Effect of the centrally acting antitussives on ascites tumor cells. | 1983 Apr |
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The nonnarcotic antitussive drug dimemorfan: a review. | 1997 Mar-Apr |
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Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes. | 2005 Jul 1 |
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[Otorhinolaringologyc approach of the chronic cough. Clinical case]. | 2007 |
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The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes. | 2010 Feb |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.drugfuture.com/mt/dropropizine.pdf
20 mg three times daily.
Route of Administration:
Oral
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NCI_THESAURUS |
C66917
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WHO-VATC |
QR05DA11
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WHO-ATC |
R05DA11
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NCI_THESAURUS |
C264
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C012621
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Dimemorfan
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CHEMBL2106325
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m4499
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SUB07158MIG
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100000082655
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DB13810
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36309-01-0
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623OAC38YU
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3037918
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DTXSID301043335
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C65399
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3497
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900
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252-963-3
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)