U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H20INO
Molecular Weight 417.2834
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AM-679 (CANNABINOID)

SMILES

CCCCCN1C=C(C(=O)C2=CC=CC=C2I)C3=C1C=CC=C3

InChI

InChIKey=GAJBHYUAJOTAEW-UHFFFAOYSA-N
InChI=1S/C20H20INO/c1-2-3-8-13-22-14-17(15-9-5-7-12-19(15)22)20(23)16-10-4-6-11-18(16)21/h4-7,9-12,14H,2-3,8,13H2,1H3

HIDE SMILES / InChI

Description

AM-679 is a drug that acts as a moderately potent agonist for the cannabinoid receptors. AM-679 is a 5-lipoxygenase-activating protein inhibitor. AM-679, found in Italy for the first time, but also identified during a seizure made by Hungarian authorities, almost concurrent with the Italian seizure.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
2.2 nM [IC50]
154.0 nM [IC50]
13.5 nM [Ki]
49.5 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Mice: topical, 60 ng AM679 in 2 ul sterile saline
Route of Administration: Topical
In Vitro Use Guide
AM-679 inhibits FLAP, as demonstrated in an in vitro human FLAP membrane binding assay with a 50% inhibitory concentration (IC50) of 2 nM and when assayed as an inhibitor of ex vivo ionophore-challenged mouse and human blood LTB4 synthesis with IC50s of 55 nM and 154 nM, respectively.