| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H44O4 |
| Molecular Weight | 432.6359 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)[C@H](O)C[C@]5(C)[C@H]4CC[C@]23C)O[C@]16CC[C@@H](C)CO6
InChI
InChIKey=FWCXELAAYFYCSR-RYKNUXCGSA-N
InChI=1S/C27H44O4/c1-15-7-10-27(30-14-15)16(2)24-23(31-27)12-20-18-6-5-17-11-21(28)22(29)13-26(17,4)19(18)8-9-25(20,24)3/h15-24,28-29H,5-14H2,1-4H3/t15-,16+,17+,18-,19+,20+,21-,22-,23+,24+,25+,26+,27-/m1/s1
Gitogenin was first extracted from the herbs of Agave Americana. This compound was found to be a selective inhibitor of UDP- glucuronosyltransferase 1A4 and α-glucosidase, and does not exhibit any inhibition of the major human CYP isoforms. In vitro experiments revealed that gitogenin moderated stimulation for the release of growth hormone from rat pituitary cells.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
| 37.2 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
SUBSTANCE RECORD
