U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H8N2
Molecular Weight 60.0983
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Ethylenediamine

SMILES

NCCN

InChI

InChIKey=PIICEJLVQHRZGT-UHFFFAOYSA-N
InChI=1S/C2H8N2/c3-1-2-4/h1-4H2

HIDE SMILES / InChI
Ethylenediamine is a strongly basic amine useful as a building block in chemical synthesis. It is used as a solvent to dissolve proteins such as albumins, casein and in medicine to stabilize aminophylline when used in injections. Ethylenediamine is used in manufacture of chelating agents (EDTA), epoxy curing agents, dimethylolethylene-urea resins, emulsifying agents, textile lubricants, antifreeze inhibitor. It is also involved in the manufacture of many industrial chemicals and forms derivatives with carboxylic acids, nitriles, alcohols, alkylating agents, carbon disulfide, aldehydes and ketones. It is a basic building block to prepare heterocyclic compound such as imidazolidines.

Approval Year

PubMed

PubMed

TitleDatePubMed
Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part II. Synthesis and configuration of (1,2-diaminoethane)bis(L-tyrosinato)cobalt(III)complex diastereomers. The crystal structure of the delta-C1-cis(O) diastereomer.
2001
Non-detection of Chlamydia species in carotid atheroma using generic primers by nested PCR in a population with a high prevalence of Chlamydia pneumoniae antibody.
2001
Modelling the sorption of metals from aqueous solutions on goethite fixed-beds.
2001
Synthesis, evaluation and structure-activity relationships of 5-alkyl-2,3-dihydroimidazo[1,2-c] quinazoline, 2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-thiones and their oxo-analogues as new potential bronchodilators.
2001
Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome.
2001
Speciation of rare earth elements in soil by sequential extraction then HPLC coupled with visible and ICP-MS detection.
2001 Aug
Hydrogen-bonded adducts of ferrocene-1,1'-diylbis(diphenylmethanol): monomeric and dimeric 1:1 adducts with 1,2-bis(4-pyridyl)ethane and 1,2-diaminoethane.
2001 Aug
[H3N(CH2)2NH3]0.5[BePO4], a beryllophosphate analogue of aluminosilicate zeolite gismondine.
2001 Aug
Biodegradability of ethylenediamine-based complexing agents and related compounds.
2001 Aug
Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate.
2001 Aug
Synthesis and structure of [K(+)-(2,2)diaza-[18]-crown-6][K3Ge9]-2ethylenediamine: stabilization of the two-dimensional layer (2)(infinity)[K3Ge9(1-)].
2001 Aug 27
Enzymatic properties of sialic acid binding lectin from Rana catesbeiana modified with a water-soluble carbodiimide in the presence of various nucleophiles.
2001 Dec
Secretion of a trypsin-like thiol protease by a new keratinolytic strain of Bacillus licheniformis.
2001 Dec 18
Cyclodehydration reactions of methyl 9,10-; 10,12-; and 9,1 2-dioxostearates with 1,2-diaminoethane under ultrasonic irradiation.
2001 Feb
Ancillary ligand effect on the properties of "Mg(thd)2" and crystal structures of [Mg(thd)2(ethylenediamine)]2, [Mg(thd)2(tmeda)], and [Mg(thd)2(trien)].
2001 Feb 12
Inhibition of lignin peroxidase-mediated oxidation activity by ethylenediamine tetraacetic acid and N-N-N'-N'-tetramethylenediamine.
2001 Jan
A new chemical synthesis of 5alpha-cholest-8(14)-en-3beta,5alpha-diol.
2001 Jan
Self-assembly and selective guest binding of three-dimensional open-framework solids from a macrocyclic complex as a trifunctional metal building block.
2001 Jan 5
[Effect of calcium ion level in blood on physiological functions in rat subjected to immersion hypothermia].
2001 Jul
Preparation of a ribonucleic acid-(polyamidoamine)-(zirconia-urea-formaldehyde resin) high-performance liquid affinity chromatographic stationary phase.
2001 Jul
catena-Poly[dibromozinc(II)-mu-ethylenediamine-N:N']: resolution of structural anomalies resulting from the interpretation of vibrational spectra.
2001 Jun
Biodegradability of ethylenediamine-based complexing agents.
2001 Jun
Prognostic importance of the soluble plasminogen activator receptor, suPAR, in plasma from rectal cancer patients.
2001 Mar
Macrochelation, cyclometallation and G-quartet formation: N3- and C8-bound PdII complexes of adenine and guanine.
2001 Mar 16
Sulfite oxidation by iron-grown cells of Thiobacillus ferrooxidans at pH 3 possibly involves free radicals, iron, and cytochrome oxidase.
2001 May
Controlled semihydrogenation of aminoalkynes using ethylenediamine as a poison of Lindlar's catalyst.
2001 May 18
A three-dimensional porous framework complex, poly[[bis(ethylenediamine)copper(II)] [potassium hexacyanocobalt(III)]].
2001 Nov
Plane-wave density functional theoretic study of formation of clay-polymer nanocomposite materials by self-catalyzed in situ intercalative polymerization.
2001 Nov 28
Gold-gold interactions as crystal engineering design elements in heterobimetallic coordination polymers.
2001 Nov 5
Synthesis and antifungal activity of 3,3'-ethylenebis(5-alkyl-1,3,5-thiadiazine-2-thiones).
2001 Oct
Polar nitrogen compounds and their behaviour in the drinking water treatment process.
2001 Oct
Predictive value of chromatin decondensation in vitro on fertilization rate after intracytoplasmic sperm injection (ICSI).
2001 Oct
Design of oxytocin antagonists, which are more selective than atosiban.
2001 Sep
Effect of modification of the carboxyl groups of the sialic acid binding lectin from bullfrog (Rana catesbeiana) oocyte on anti-tumor activity.
2001 Sep
Syntheses, vibrational spectra, and theoretical studies of the adamantanoid Sn(4)Ch(10)(4-) (Ch = Se, Te) anions: X-ray crystal structures of [18-crown-6-K](4)[Sn4Se10]*5en and [18-crown-6-K](4)[Sn4Te10]*3en*2THF.
2001 Sep 10
Utilization of quinolone drugs as monomers: characterization of the synthesis reaction products for poly(norfloxacin diisocyanatododecane polycaprolactone).
2001 Spring
[Occupational asthma due to amines].
2002 Feb
Bis(ethylenediamine)copper(II) bis(O,O'-diethyl dithiophosphate).
2002 Feb
Molecular characteristics of glnA linked mutations in the nitrogen-fixing cyanobacterium Nostoc muscorum.
2002 Feb
Schiff bis bases: analytical reagents. II. Spectrophotometric determination of manganese from pharmaceutical forms.
2002 Feb 1
Structure-directing coordination template effect of ethylenediamine in formations of ZnS and ZnSe nanocrystallites via solvothermal route.
2002 Feb 25
Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.
2002 Jan
Optimization of urease immobilization onto non-porous HEMA incorporated poly(EGDMA) microbeads and estimation of kinetic parameters.
2002 Jan
Galactosylated alginate as a scaffold for hepatocytes entrapment.
2002 Jan
Syntheses, crystal structures, and density functional theory calculations of the closo-[1-M(CO)(3)(eta(4)-E(9))](4-) (E = Sn, Pb; M = Mo, W) cluster anions and solution NMR spectroscopic characterization of [1-M(CO)(3)(eta(4)-Sn(9))](4-) (M = Cr, Mo, W).
2002 Jan 14
Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum.
2002 Jan 2
Gramicidin derivatives as membrane-based pH sensors.
2002 Jan 2
Direct synthesis of peptides on convective interaction media monolithic columns for affinity chromatography.
2002 Jan-Feb
Designed self-assembly of molecular necklaces.
2002 Mar 13
Role of magnesium in nucleotide exchange on the small G protein rac investigated using novel fluorescent Guanine nucleotide analogues.
2002 Mar 19
Patents
Name Type Language
Ethylenediamine
EP   HSDB   II   MART.   MI   USP   WHO-DD  
Systematic Name English
ETHYLENEDIAMINE [MART.]
Common Name English
ETHYLENE DIAMINE
Common Name English
ETHYLENEDIAMINE [HSDB]
Common Name English
ETHYLENEDIAMINE [II]
Common Name English
ETHYLENEDIAMINE [EP MONOGRAPH]
Common Name English
Ethylenediamine [WHO-DD]
Common Name English
ETHYLENEDIAMINE [INCI]
Common Name English
1,2-DIAMINOETHANE
Systematic Name English
1,2-ETHANEDIAMINE
Systematic Name English
ETHYLENEDIAMINE [JAN]
Common Name English
edamine [INN]
Common Name English
ETHYLENEDIAMINE [USP MONOGRAPH]
Common Name English
EDAMINE
INN  
INN  
Official Name English
ETHYLENEDIAMINE [MI]
Common Name English
TIZANIDINE HYDROCHLORIDE IMPURITY H [EP IMPURITY]
Common Name English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
EPA PESTICIDE CODE 4205
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
CFR 21 CFR 173.320
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
Code System Code Type Description
RXCUI
4158
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY RxNorm
INN
7141
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY Allergens [Chemical/Ingredient]
MERCK INDEX
m5119
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB14189
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
ChEMBL
CHEMBL816
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
CONCEPT Industrial Aid
PUBCHEM
3301
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
FDA UNII
60V9STC53F
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
ECHA (EC/EINECS)
203-468-6
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
CHEBI
30347
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
EVMPD
SUB13760MIG
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
CAS
107-15-3
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
WIKIPEDIA
ETHYLENEDIAMINE
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
DAILYMED
60V9STC53F
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY Cell-mediated Immunity [PE]
EPA CompTox
DTXSID5021881
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
NCI_THESAURUS
C80898
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
SMS_ID
100000092194
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
HSDB
535
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 15 14:57:53 GMT 2023 , Edited by admin on Fri Dec 15 14:57:53 GMT 2023
PRIMARY Increased Histamine Release [PE]