Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H14N5O3.Na |
| Molecular Weight | 287.2503 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].NC1=NC2=C(N=CN2C[C@]3(CO)C[C@H]3CO)C(=O)[N-]1
InChI
InChIKey=HNYNXSYKXVHGKX-BJUCTQDSSA-M
InChI=1S/C11H15N5O3.Na/c12-10-14-8-7(9(19)15-10)13-5-16(8)3-11(4-18)1-6(11)2-17;/h5-6,17-18H,1-4H2,(H3,12,14,15,19);/q;+1/p-1/t6-,11-;/m0./s1
Eprociclovir (A5021, 9-[[cis-1', 2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine) is a nucleoside analog with antiviral activity. Antiviral activity of eprociclovir appears to depend rapid and stable accumulation of its triphosphate in infected cells and on inhibition of viral DNA polymerase by its triphosphate. Eprociclovir was shown to be a potent inhibitor of the replication of herpes simplex virus type 1, 2, 6, Epstein-Barr virus and varicella zoster virus, both in vitro and in vivo.
Eprociclovir development has been discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vitro and in vivo assessment of eprociclovir as antiviral treatment against testudinid herpesvirus 3 in Hermann's tortoise (Testudo hermanni). | 2019-06 |
|
| Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo. | 2001-02 |
|
| Evaluation of anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]- guanine (A-5021) in mice. | 1999-06 |
|
| Mode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus. | 1998-08 |
|
| Antiherpesvirus activities of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) in cell culture. | 1998-07 |
|
| Synthesis and antiviral activity of novel acyclic nucleosides: discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses. | 1998-04-09 |
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| Code System | Code | Type | Description | ||
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219657-36-0
Created by
admin on Mon Mar 31 18:05:34 GMT 2025 , Edited by admin on Mon Mar 31 18:05:34 GMT 2025
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PRIMARY | |||
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60T510Q498
Created by
admin on Mon Mar 31 18:05:34 GMT 2025 , Edited by admin on Mon Mar 31 18:05:34 GMT 2025
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PRIMARY | |||
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1434875-92-9
Created by
admin on Mon Mar 31 18:05:34 GMT 2025 , Edited by admin on Mon Mar 31 18:05:34 GMT 2025
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NON-SPECIFIC STOICHIOMETRY | |||
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91617680
Created by
admin on Mon Mar 31 18:05:34 GMT 2025 , Edited by admin on Mon Mar 31 18:05:34 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
