| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H13FNO |
| Molecular Weight | 122.1612 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
C[N+](C)(CF)CCO
InChI
InChIKey=PBVFROWIWWGIFK-UHFFFAOYSA-N
InChI=1S/C5H13FNO/c1-7(2,5-6)3-4-8/h8H,3-5H2,1-2H3/q+1
Fluorocholine is (18F-fluorocholine) is a specific promising agent for imaging tumor cell proliferation, particularly in prostate cancer, using PET/CT. Fluorocholine is a beneficial tool in the early detection of marrow-based metastases because it excludes distant metastases and evaluates the response to hormone therapy. In addition, 18F-fluorocholine has the potential to differentiate between degenerative and malignant osseous abnormalities because degenerative changes are not choline-avid.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Patients were injected with 100 MBq of 18F-fluorocholine
Route of Administration:
Intravenous
The incorporation of [18F]FDG and [18F]FCH (Fluorocholine) was determined through the uptake of the radiotracer into the trichloroacetic acid-insoluble cellular fraction of tumor cell lines. Briefly, cells were seeded in 96-well plates at 10,000 cells per well. After 30 min of incubation with 500 μCi/ml of [18F]FDG or [18F]FCH, cells were washed twice in icecold PBS and precipitated with ice-cold 5% trichloroacetic acid. Then, cells were washed once with ice-cold 95% ethanol and solubilized with 1N NaOH. An aliquot was neutralized, and the radioactivity was determined in a liquid scintillation counter. All experiments were performed in triplicate. A measurable uptake of [18F]FCH and [18F]FDG was observed in the five tumor cell lines. The incorporation of both tracers increased from 10 to 60 min.
SUBSTANCE RECORD
