Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H5N.H3O4P |
Molecular Weight | 177.0951 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OP(O)(O)=O.C1=CC=NC=C1
InChI
InChIKey=HOJLDGRYURJOJS-UHFFFAOYSA-N
InChI=1S/C5H5N.H3O4P/c1-2-4-6-5-3-1;1-5(2,3)4/h1-5H;(H3,1,2,3,4)
Pyridine is a basic heterocyclic organic compound used as a solvent in organic synthesis. Since the pyridine ring has three double bonds, six p-electrons exist, which are sufficient for aromatic ring formation without involving the lone pair electrons of the nitrogen atom. Since the lone pair electrons remain free, quaternary salts retain the aromaticity. However, the nitrogen atom has a higher electronegativity than the carbon atoms and shows an electron-withdrawing effect. In oxidation and reduction reactions, the pyridine ring exhibits properties characteristic of pelectron-deficient aromatic rings: resistance to oxidation and facile reduction. Pyridine bases are a constituent of tars. They were isolated from coal tar or coal gas before synthetic manufacturing processes became established. Pyridine is an excellent solvent, especially for dehydrochlorination reactions and extraction of antibiotics. Large amounts of pyridine are used as starting material for pharmaceuticals and agrochemicals: for example, herbicides such as diquat and paraquat, insecticides such as chlorpyrifos, and fungicides such as pyrithione. Pyridine is harmful if inhaled, swallowed or absorbed through the skin. Effects of acute pyridine intoxication include dizziness, headache, lack of coordination, nausea, salivation, and loss of appetite.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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Adulteration of urine by "Urine Luck". | 1999 Jul |
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Constitutive and induced expression by pyridine and beta-naphthoflavone of rat CYP1A is sexually dimorphic. | 1999 Jun-Jul |
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Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. | 2000 Feb-Mar |
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Fluorescent and electroactive cyclic assemblies from perylene tetracarboxylic acid bisimide ligands and metal phosphane triflates. | 2001 |
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Reversible vacuolation of T-tubules in skeletal muscle: mechanisms and implications for cell biology. | 2001 |
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Characterization of the flavoprotein domain of gp91phox which has NADPH diaphorase activity. | 2001 Apr |
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Presynaptic function is altered in snake K+-depolarized motor nerve terminals containing compromised mitochondria. | 2001 Apr 1 |
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Determination of the disulfide structure of sillucin, a highly knotted, cysteine-rich peptide, by cyanylation/cleavage mass mapping. | 2001 Apr 17 |
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Two new elastin cross-links having pyridine skeleton. Implication of ammonia in elastin cross-linking in vivo. | 2001 Apr 20 |
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Photoreaction of 2-halo-N-pyridinylbenzamide: intramolecular cyclization mechanism of phenyl radical assisted with n-complexation of chlorine radical. | 2001 Apr 6 |
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New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY--radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey. | 2001 Feb |
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Cytoplasmic Ca2+ at low submicromolar concentration stimulates mitochondrial metabolism in rat luteal cells. | 2001 Feb |
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Spectrochemical investigations in molecularly organized solvent media: evaluation of pyridinium chloride as a selective fluorescence quenching agent of polycyclic aromatic hydrocarbons in aqueous carboxylate-terminated poly(amido) amine dendrimers and anionic micelles. | 2001 Feb |
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Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology. | 2001 Feb |
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[Ring cleavage of N-arylpyridinium salts by nucleophiles--regioselectivity and stereochemistry of the products. 1]. | 2001 Feb |
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Interaction of stoned and synaptotagmin in synaptic vesicle endocytosis. | 2001 Feb 15 |
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Improvement of graft function without donor pretreatment in liver transplantation from non-heart-beating donors. | 2001 Feb-Mar |
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NBD-labeled phosphatidylcholine and phosphatidylethanolamine are internalized by transbilayer transport across the yeast plasma membrane. | 2001 Jan |
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N-(8-Quinolyl)pyridine-2-carboxamide. | 2001 Jan |
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Fatty acid chain elongation synthesis in eel (Anguilla anguilla) liver mitochondria. | 2001 Jan |
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Hydrogen peroxide acts as a second messenger for the induction of defense genes in tomato plants in response to wounding, systemin, and methyl jasmonate. | 2001 Jan |
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Synthesis, characterization, solid-state molecular structures, and deprotonation reactions of cationic alcohol complexes of osmium nitrosyl porphyrins. | 2001 Jan 1 |
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Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networks. | 2001 Jan 1 |
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A covalent vanadium(III) 2-dimensional network and vanadyl chains linked by aryldioxides. | 2001 Jan 15 |
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Mono- and dinuclear zinc complexes derived from unsymmetric binucleating ligands: synthesis, characterization, and formation of tetranuclear arrays. | 2001 Jan 15 |
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Dinuclear alkyldiamine platinum antitumor compounds: a structure-activity relationship study. | 2001 Jan 18 |
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Control of synapse number by glia. | 2001 Jan 26 |
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Capillary zone electrophoresis of basic analytes in methanol as non-aqueous solvent mobility and ionisation constant. | 2001 Jan 5 |
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Self-assembly and selective guest binding of three-dimensional open-framework solids from a macrocyclic complex as a trifunctional metal building block. | 2001 Jan 5 |
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New eudesmane sesquiterpenes from the root of Lindera strychnifolia. | 2001 Mar |
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Monooxygenases involved in GA12 and GA14 synthesis in Gibberella fujikuroi. | 2001 Mar |
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Metabolism of the beta-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-beta-hydroxypropylpropylamine and N-nitroso-beta-oxopropylpropylamine. | 2001 Mar |
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Optimization of force constants with an Urey-Bradley force field avoiding normal mode crossings. | 2001 Mar 1 |
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Fragment mode analysis and its application to the vibrational normal modes of boron trichloride-ammonia and boron trichloride-pyridine complexes. | 2001 Mar 1 |
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Scanning tunneling microscopy with chemically modified tips: discrimination of porphyrin centers based on metal coordination and hydrogen bond interactions. | 2001 Mar 1 |
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Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones. | 2001 Mar 1 |
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Excited-state properties of Rh(2)(O(2)CCH(3))(4)(L)(2) (L = CH(3)OH, THF, PPh(3), py). | 2001 Mar 12 |
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Highly energetic tetraazidoborate anion and boron triazide adducts. | 2001 Mar 12 |
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Crystal structure analysis and chiral recognition study of Delta-[Ru(bpy)2(py)2][(+)-O,O'-dibenzoylD-tartrate].12H2O and Lambda-[Ru(bpy)2(py)2][(-)-O,O'-dibenzoyl-L-tartrate].12H2O. | 2001 Mar 12 |
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A pyridine-thiol ligand with multiple bonding sites for heavy metal precipitation. | 2001 Mar 19 |
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Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase. | 2001 Mar 2 |
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Probing the influence of local coordination environment on the properties of Fe-type nitrile hydratase model complexes. | 2001 Mar 26 |
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A synthetic, structural, magnetic, and spectral study of several [Fe[tris(pyrazolyl)methane]2](BF4)2 complexes: observation of an unusual spin-state crossover. | 2001 Mar 26 |
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Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons. | 2001 Mar 5 |
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Inhibition of Shiga toxin-induced tumor necrosis factor-alpha production and gene expression in human monocytic cells by CV6209. | 2001 Mar 9 |
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Determination of thiodyglycol in groundwater using solid-phase extraction followed by gas chromatography with mass spectrometric detection in the selected-ion mode. | 2001 Mar 9 |
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NAD/NADH models with axial/central chiralities: superiority of the quinoline ring system. | 2001 Mar 9 |
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Mapping action potentials and calcium transients simultaneously from the intact heart. | 2001 May |
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Deformation-induced lipid trafficking in alveolar epithelial cells. | 2001 May |
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Inhibition of ATP-induced surfactant exocytosis by dihydropyridine (DHP) derivatives: a non-stereospecific, photoactivated effect and independent of L-type Ca2+ channels. | 2001 May 1 |
Patents
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5Z223840E1
Created by
admin on Sat Dec 16 12:12:47 GMT 2023 , Edited by admin on Sat Dec 16 12:12:47 GMT 2023
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35175-38-3
Created by
admin on Sat Dec 16 12:12:47 GMT 2023 , Edited by admin on Sat Dec 16 12:12:47 GMT 2023
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10866885
Created by
admin on Sat Dec 16 12:12:47 GMT 2023 , Edited by admin on Sat Dec 16 12:12:47 GMT 2023
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