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Details

Stereochemistry ABSOLUTE
Molecular Formula C13H18O7
Molecular Weight 286.2778
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GASTRODIN

SMILES

OC[C@H]1O[C@@H](OC2=CC=C(CO)C=C2)[C@H](O)[C@@H](O)[C@@H]1O

InChI

InChIKey=PUQSUZTXKPLAPR-UJPOAAIJSA-N
InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1

HIDE SMILES / InChI

Description

Gastrodin is the main bioactive component of Gastrodia elata Blume (G. elata). Tian Ma Su Zhu She Ye (contains Gastrodin) It is an extensively used in the clinical practice of traditional Chinese medicine, to treat neurasthenia, neurasthenia syndrome, angioneurotic headache disorder, traumatic brain syndrome, vertigo meniere disease, medicinal with dizziness, vertigo, sudden deafness, vestibular neuronitis, vertebral basilar artery blood supply deficiency, etc. Apart from traditional claims, scientific reports support the antioxidative, anticonvulsive, antiinflammatory, antiepileptic, antiobesity, anxiolytic, and learning and memory improvements in activities of gastrodin

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
1.94 µM [Kd]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown
Primary
Unknown
Primary
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
1484.55 ng/mL
200 mg single, oral
GASTRODIN plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
7210.26 ng × h/mL
200 mg single, oral
GASTRODIN plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
6.06 h
200 mg single, oral
GASTRODIN plasma
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
Gastrodin injection (unspecified dosage) is beneficial to old patients with refractory hypertension. Gastrodin (50 - 100 mg/kg, intraperitoneally) can decrease the volume of cerebral infarction, ameliorate the cerebral injury in the rats of cerebral ischemia-reperfusion.
Route of Administration: Parenteral
In Vitro Use Guide
Gastrodin could effectively promote proliferation of rat RSC96 Schwann cells in a dose- and time-dependent manner. The best performance was obtained at the concentration of 200μM.