Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H14ClN3O2S |
| Molecular Weight | 311.787 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(Cl)C(C)=C2C(SC(C(=O)NC3CC3)=C2N)=N1
InChI
InChIKey=CTEGQKDJTBWFHW-UHFFFAOYSA-N
InChI=1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19940843 | https://www.ncbi.nlm.nih.gov/pubmed/22610522 | https://www.ncbi.nlm.nih.gov/pubmed/24700389
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19940843 | https://www.ncbi.nlm.nih.gov/pubmed/22610522 | https://www.ncbi.nlm.nih.gov/pubmed/24700389
LY2033298 is a selective allosteric modulator for muscarinic acetylcholine M4 receptor. It exerts antipsychotic action in animal models. The compound is able to modulate circadian activity rhythms and morphine-induced conditioned place preference in rats.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18678919 | https://www.ncbi.nlm.nih.gov/pubmed/19940843
Curator's Comment: LY2033298 is CNS active in animals. No human data available.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats. | 2014-10 |
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| LY2033298, a positive allosteric modulator at muscarinic M₄ receptors, enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. | 2012-11 |
|
| Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects. | 2012-01 |
|
| The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor. | 2011-05 |
|
| Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor. | 2011-04 |
|
| Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms. | 2010-06-18 |
|
| Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties. | 2010-03 |
|
| New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). | 2008-10 |
|
| Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. | 2008-08-05 |
Patents
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886047-13-8
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5YG6JK4ECM
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11536903
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DTXSID10468233
Created by
admin on Mon Mar 31 21:53:27 GMT 2025 , Edited by admin on Mon Mar 31 21:53:27 GMT 2025
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ACTIVE MOIETY
