U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C18H24NO2S
Molecular Weight 318.454
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of TIEMONIUM

SMILES

C[N+]3(CCC(O)(C1=CC=CS1)C2=CC=CC=C2)CCOCC3

InChI

InChIKey=HJDYAOBDPZQHOD-UHFFFAOYSA-N
InChI=1S/C18H24NO2S/c1-19(11-13-21-14-12-19)10-9-18(20,17-8-5-15-22-17)16-6-3-2-4-7-16/h2-8,15,20H,9-14H2,1H3/q+1

HIDE SMILES / InChI

Description

Tiemonium (often used in a form of iodide or methylsulphate salt) is a muscarinic acetylcholine receptor antagonist, which is available in Asia (mainly Bangladesh) for the alleviation of muscle spasms of the intestine, biliary system, uterus and urinary bladder in gastrointestinal, biliary, urinary and gynecological diseases.

Approval Year

PubMed

PubMed

TitleDatePubMed
Orofacial dyskinesia associated with tiemonium.
2007 Dec
Direct asymmetric catalytic thienylaluminum addition to ketones: a concise approach to the synthesis of (S)-tiemonium iodide.
2009 Aug 6
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds.
2010 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Recommended oral dose of tiemonium (in form of methylsulphate salt) tablet is 2-6 tablets (100-300 mg) daily in divided dosage as required. Tiemonium can be also given as an injection (5 or 10 mg) three times daily, through Intravenous route or Intramuscular route. Suppository: recommended dose is 1 suppository (each suppository contains 20 mg methylsulphate salt) two or three times daily, through rectal route.
Route of Administration: Oral; Intravenous; Inramuscular; Rectal
In Vitro Use Guide
Human colon cancer cell lines, LOVO, were incubated in 2 ml of fresh complete medium containing 10(-2) M tiemonium methylsulfate for five days. Under the tested concentration tiemonium methylsulfate lead to a decrease of cell proliferation.
Name Type Language
TIEMONIUM
WHO-DD  
Common Name English
TIEMONIUM [WHO-DD]
Common Name English
4-(3-HYDROXY-3-PHENYL-3-(2-THIENYL)PROPYL)-4-METHYL-MORPHOLINIUM
Systematic Name English
TIEMONIUM ION
Common Name English
TIEMONIUM CATION
Common Name English
Classification Tree Code System Code
WHO-ATC A03AB17
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
NCI_THESAURUS C29704
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
WHO-ATC A03DA07
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
Code System Code Type Description
RXCUI
236188
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY RxNorm
NCI_THESAURUS
C84209
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY
WIKIPEDIA
Tiemonium
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY
CAS
6252-92-2
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY
PUBCHEM
5473
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY
ECHA (EC/EINECS)
228-380-5
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY
EVMPD
SUB15570MIG
Created by admin on Tue Oct 22 06:04:09 UTC 2019 , Edited by admin on Tue Oct 22 06:04:09 UTC 2019
PRIMARY