PROMOLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H23NO4
Molecular Weight	293.3581
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(OC1=CC=CC=C1)C(=O)OCCN2CCOCC2

InChI

InChIKey=GMISKEUWHIRDNK-UHFFFAOYSA-N

InChI=1S/C16H23NO4/c1-16(2,21-14-6-4-3-5-7-14)15(18)20-13-10-17-8-11-19-12-9-17/h3-7H,8-13H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4242953 | https://www.ncbi.nlm.nih.gov/pubmed/5453229

Promolate is an Isobutyric acid derivative with potent antitussive activity. In preclinical studies, Promolate shows low toxicity in experimental animals and an antitussive action like that of codeine, but without the side effects of the latter. Promolate displayed a dose-dependent antitussive effect in conscious guinea pigs with coughing induced by NH3 aerosol. The activity of Promolate did not diminish when it was administered orally to guinea pigs for 20 days. Promolate also displayed a dose-dependent antitussive effect in Na barbital anesthetized cats with coughing induced by stimulation of the superior laryngeal nerve. High doses of Promolate administered to rats for 125 days did not provoke side effects.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological activities of a new antitussive agent: morphethylbutyne (2-phenoxy-isobutyric acid, 2-morpholine-ethyl ester).	1969-04	4242953

Patents

Sample Use Guides

In Vivo Use Guide

guinea pig: 400-1400 mg/kg orally or rectally

Route of Administration: Oral

Name

Type

Language

ATUSIL

Preferred Name

English

PROMOLATE

Official Name

English

PROMOLATE [MART.]

Common Name

English

Promolate [WHO-DD]

Common Name

English

promolate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698