Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H12O4 |
| Molecular Weight | 172.1785 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)\C=C\C(=O)OCC
InChI
InChIKey=IEPRKVQEAMIZSS-AATRIKPKSA-N
InChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5+
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats. | 1984 Apr |
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| Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione. | 1995 Feb 1 |
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| Induction of metalloelastase mRNA in murine peritoneal macrophages by diethylmaleate. | 1999 Apr 19 |
|
| Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase. | 2000 Aug |
|
| Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. | 2002 Nov 22 |
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| Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. | 2003 Jun |
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| Effect of acrolein and glutathione depleting agents on thioredoxin. | 2004 Nov 15 |
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| Spatial activities and induction of glutamate-cysteine ligase (GCL) in the postimplantation rat embryo and visceral yolk sac. | 2004 Oct |
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| Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. | 2007 Nov |
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| Peroxiredoxin 2 and peroxidase enzymatic activity of mammalian spermatozoa. | 2009 Jun |
|
| Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells. | 2010 May 15 |
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| A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. | 2010 Sep |
|
| An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. | 2011 Dec |
|
| Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent. | 2011 Jan 14 |
|
| The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. | 2012 Jan |
|
| Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells. | 2014 Feb |
|
| A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015 Dec |
Patents
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| Code System | Code | Type | Description | ||
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638144
Created by
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623-91-6
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5722
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5WBU5A3E8A
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20954
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C035088
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210-819-7
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DTXSID7027253
Created by
admin on Fri Dec 15 17:39:35 GMT 2023 , Edited by admin on Fri Dec 15 17:39:35 GMT 2023
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SUBSTANCE RECORD
