SULOCARBILATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H12N2O5S
Molecular Weight	260.267
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC=C(NC(=O)OCCO)C=C1

InChI

InChIKey=UHXMTGXWCGEIQE-UHFFFAOYSA-N

InChI=1S/C9H12N2O5S/c10-17(14,15)8-3-1-7(2-4-8)11-9(13)16-6-5-12/h1-4,12H,5-6H2,(H,11,13)(H2,10,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13543785 | https://www.ncbi.nlm.nih.gov/pubmed/13617393

Sulocarbilate (also known as W-1548-1) is a sulfanilamide derivative and carbonic anhydrase inhibitor with diuretic activity. In preclinical models, Sulocarbilate shows similar efficacy and superior safety profile compared to other agents of this type. Clinically, Sulocarbilate shows the maximum effect as a natriuretic agent in an oral daily dose of 2 g.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carbonic anhydrase 6 Target ID: CHEMBL2095180 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13617393 \| https://www.ncbi.nlm.nih.gov/pubmed/13543785	Inhibitor 8504

PubMed

Title	Date	PubMed
Observations on sulocarbilate as an orally active carbonic anhydrase inhibitor diuretic agent.	1958-04	13543785

Patents

Sample Use Guides

In Vivo Use Guide

2 g/day

Route of Administration: Oral

Name

Type

Language

sulocarbilate [INN]

Preferred Name

English

SULOCARBILATE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C448