Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C47H79O17.H4N |
Molecular Weight | 934.1584 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 24 / 24 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[NH4+].[H][C@@]1(C[C@H](O[C@]2([H])C[C@H](OC)[C@@H](OC)[C@H](C)O2)[C@@]([H])(O1)[C@]3(C)CC[C@@]([H])(O3)[C@]4(C)CC[C@]5(C[C@H](O)[C@@H](C)[C@]([H])(O5)[C@@H](C)[C@]6([H])O[C@](O)(CC([O-])=O)[C@@H](C)[C@H](OC)[C@H]6OC)O4)[C@@]7([H])O[C@](C)(O)[C@H](C)C[C@@H]7C
InChI
InChIKey=WQGJEAMPBSZCIF-HKSLRPGUSA-N
InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1
Maduramicin is antibiotic isolated from actinobacteria Actinomadura rubra. Maduramicin is used in veterinary as an aid in the prevention of coccidiosis in broiler chickens and turkeys. The compound is reported to be toxic to animals and humans if improperly used or by accident, resulting in heart failure, skeletal muscle degeneration, and even death. Studies have shown that toxicity is due to activation of protein phosphatase 2A, and the manipulation of the ROS-PTEN-Akt-Erk1/2 pathway may be a potential approach to prevent maduramicin -induced cardiotoxicity.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4703 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29241734 |
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Target ID: P60484 Gene ID: 5728.0 Gene Symbol: PTEN Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/30511398 |
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CFR |
21 CFR 558.340
Created by
admin on Fri Dec 15 18:48:51 GMT 2023 , Edited by admin on Fri Dec 15 18:48:51 GMT 2023
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WHO-VATC |
QP51AX10
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admin on Fri Dec 15 18:48:51 GMT 2023 , Edited by admin on Fri Dec 15 18:48:51 GMT 2023
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CFR |
21 CFR 556.375
Created by
admin on Fri Dec 15 18:48:51 GMT 2023 , Edited by admin on Fri Dec 15 18:48:51 GMT 2023
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Code System | Code | Type | Description | ||
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Maduramicin
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C166861
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84878-61-5
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U-67
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5U912U22T2
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SUB08632MIG
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100000081717
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DTXSID4048983
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DB11525
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68595
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5670
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CHEMBL1909065
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C018091
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m6981
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PRIMARY | Merck Index |
ACTIVE MOIETY
SUBSTANCE RECORD