U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment: description was created based on several sources, including: https://circabc.europa.eu/sd/a/f184c262-d783-48ca-9050-67e5e3098d57/Abamectin%20(assessment%20report%20as%20finalised%20on%2018.02.11).pdf | https://www.ncbi.nlm.nih.gov/pubmed/24451653 | https://www.ncbi.nlm.nih.gov/pubmed/12878275

Abamectin is a mixture of avermectins containing avermectin B1a and avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal or anthelmintic compounds derived from the soil bacterium Streptomyces avermitilis. Abamectin is used to control insect and mite pests of a range of agronomic, fruit, vegetable and ornamental crops and it is used by homeowners for control of fire ants. Abamectin acts on insects by interfering with neural and neuromuscular transmission. Abamectin attenuated ethanol-induced gastric ulceration. Chemical structure and effects on GABAARs and P2X4Rs receptor function play key roles in the ability of avermectin to reduce ethanol intake

CNS Activity

Originator

Approval Year

2024
711
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2752
Agonist
2752
Activator
1447
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Preclinical
Unknown

Approved Use

Unknown
Preventing
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Survival and development of bullfrog tadpoles in microcosms treated with abamectin.
2017-08
Lactational exposure to abamectin induced mortality and adverse biochemical and histopathological effects in suckling pups.
2017-04
Efficacy of abamectin injection against Dermatobia hominis in cattle.
1993
Abamectin in the ambient air, on surfaces, and in food of dining facilities treated for cockroaches.
1992-08
Abamectin: toxicity to house flies (Diptera: Muscidae) resistant to synthetic organic insecticides.
1986-06
Patents

Patents

JP4851094B2
1
JPH09104695A
1

Sample Use Guides

In Vivo Use Guide
Mouse: 5 mg/kg
Route of Administration: Intraperitoneal
In Vitro Use Guide
Sources: DOI: 10.1007/s11802-007-0369-y
The cytotoxicity of abamectin to the Gill Cell Line of Flounder (FG cell line) was examined. It was revealed that the proliferation of the cells was inhibited at all concentrations of abamectin tested. The cell density was 3.38×10^3 cells mm-2 after culture for 8 days. When the cells were cultured in the presence of 5, 10, 15 and 20 μmolL-1 abamectin for the same periods, the cell densities were reduced to 2.99×10^3 , 2.50×10^3 , 2.16×10^3 and 1.59×10^3 cells mm-2, respectively.
Name Type Language
ABAMECTIN
HSDB   INN   ISO   MART.   MI   USAN  
USAN   INN  
Official Name English
AGRI-MEK
Preferred Name English
DORATECT
Brand Name English
MK-936
Code English
ABAMECTIN [MART.]
Common Name English
ZECTIN
Brand Name English
AVID
Brand Name English
abamectin [INN]
Common Name English
ABAMECTIN [ISO]
Common Name English
BOVITIN
Brand Name English
NSC-758202
Code English
PARAFOIL
Brand Name English
DUOTIN
Brand Name English
ENDECTO
Brand Name English
ENZEK
Brand Name English
MK-0936
Code English
DUOMECTIN
Brand Name English
AVOMEC
Brand Name English
AVERMECTIN B1
Common Name English
ENZEC
Brand Name English
ZEPHYR
Brand Name English
VERTIMIL
Brand Name English
ABAMECTIN [HSDB]
Common Name English
ABAMECTIN [USAN]
Common Name English
A MIXTURE CONSISTING OF 80% OR MORE OF ABAMECTIN COMPONENT B1A AND 20% OR LESS OF ABAMECTIN COMPONENT B1B
Common Name English
ABAMECTIN [MI]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 122804
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
NCI_THESAURUS C250
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
WHO-VATC QP54AA02
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
WHO-VATC QP54AA52
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C95196
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
FDA UNII
5U8924T11H
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
SMS_ID
300000024011
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
NSC
758202
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
HSDB
6941
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
INN
5677
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
EPA CompTox
DTXSID8023892
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
ChEMBL
CHEMBL3215298
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
MESH
C048324
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
CHEBI
39214
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
MERCK INDEX
m1272
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY Merck Index
WIKIPEDIA
ABAMECTIN
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
USAN
W-60
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
ALANWOOD
abamectin
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
CAS
71751-41-2
Created by admin on Mon Mar 31 18:34:05 GMT 2025 , Edited by admin on Mon Mar 31 18:34:05 GMT 2025
PRIMARY
All of the following components must be present:
Structure of ABAMECTIN B1A
Structure of ABAMECTIN B1B
SUBSTANCE RECORD
ABAMECTIN
Definition References
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966