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Details

Stereochemistry EPIMERIC
Molecular Formula 6C30H32Cl3NO.C16H26O5
Molecular Weight 3472.016
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 14
E/Z Centers 6
Charge 0

SHOW SMILES / InChI
Structure of LUMEFANTRINE CO-ARTEMETHER

SMILES

[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@]4(C)OO[C@@]13[C@]([H])(O[C@H](OC)[C@@H]2C)O4.CCCCN(CCCC)CC(O)C5=CC(Cl)=CC6=C5C7=CC=C(Cl)C=C7\C6=C\C8=CC=C(Cl)C=C8.CCCCN(CCCC)CC(O)C9=CC(Cl)=CC%10=C9C%11=CC=C(Cl)C=C%11\C%10=C\C%12=CC=C(Cl)C=C%12.CCCCN(CCCC)CC(O)C%13=CC(Cl)=CC%14=C%13C%15=CC=C(Cl)C=C%15\C%14=C\C%16=CC=C(Cl)C=C%16.CCCCN(CCCC)CC(O)C%17=CC(Cl)=CC%18=C%17C%19=CC=C(Cl)C=C%19\C%18=C\C%20=CC=C(Cl)C=C%20.CCCCN(CCCC)CC(O)C%21=CC(Cl)=CC%22=C%21C%23=CC=C(Cl)C=C%23\C%22=C\C%24=CC=C(Cl)C=C%24.CCCCN(CCCC)CC(O)C%25=CC(Cl)=CC%26=C%25C%27=CC=C(Cl)C=C%27\C%26=C\C%28=CC=C(Cl)C=C%28

InChI

InChIKey=VZQXHIJHMCHBNW-UFIXNTOBSA-N
InChI=1S/6C30H32Cl3NO.C16H26O5/c6*1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28;1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h6*7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3;9-14H,5-8H2,1-4H3/b6*25-15-;/t;;;;;;9-,10-,11+,12+,13+,14-,15-,16-/m......1/s1

HIDE SMILES / InChI
Lumefantrine Co-Artemether is a tablet formulation of artemether and lumefantrine, a well-tolerated, fast-acting and effective blood schizontocidal drug that serves primarily in the treatment of uncomplicated falciparum malaria that is resistant to other antimalarials. Artemether, an artemisinin derivative, has several proposed mechanisms of action, including interference with plasmodial transport proteins, interference with mitochondrial electron transport, and the production of free radicals to reduce blood antioxidants and glutathione. While artemether results in rapid defervescence, parasite clearance, and clinical improvement, it also has a relatively high recrudescence rate when used as monotherapy. The exact mechanism of action of lumefantrine is not well defined, but it is thought to inhibit -hematin formation, an important detoxification pathway for the parasite. Unlike artemether, lumefantrine has a slower onset of action, resulting in clearance of residual parasites and a decrease in recrudescence rate. The combination is an effective and well-tolerated malaria treatment, providing high cure rates even in areas of multi-drug resistance.

Approval Year

Name Type Language
LUMEFANTRINE CO-ARTEMETHER
MI  
Common Name English
RIAMET
Brand Name English
CPG-56697
Code English
LUMEFANTRINE CO-ARTEMETHER [MI]
Common Name English
COARTEM
Brand Name English
FIXED 6:1 LUMEFANTRINE MIXTURE WITH ARTEMETHER
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID70894857
Created by admin on Sat Dec 16 11:08:23 GMT 2023 , Edited by admin on Sat Dec 16 11:08:23 GMT 2023
PRIMARY
PUBCHEM
6450800
Created by admin on Sat Dec 16 11:08:23 GMT 2023 , Edited by admin on Sat Dec 16 11:08:23 GMT 2023
PRIMARY
MERCK INDEX
m6927
Created by admin on Sat Dec 16 11:08:23 GMT 2023 , Edited by admin on Sat Dec 16 11:08:23 GMT 2023
PRIMARY Merck Index
FDA UNII
5T2U51A0MW
Created by admin on Sat Dec 16 11:08:23 GMT 2023 , Edited by admin on Sat Dec 16 11:08:23 GMT 2023
PRIMARY
DRUG BANK
DB13085
Created by admin on Sat Dec 16 11:08:23 GMT 2023 , Edited by admin on Sat Dec 16 11:08:23 GMT 2023
PRIMARY
CAS
141204-94-6
Created by admin on Sat Dec 16 11:08:23 GMT 2023 , Edited by admin on Sat Dec 16 11:08:23 GMT 2023
PRIMARY