CHALCONE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H12O
Molecular Weight	208.2552
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(\C=C\C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=DQFBYFPFKXHELB-VAWYXSNFSA-N

InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.	2015-02	25349334
2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.	2013-05-25	23562496
Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.	2012-11-19	23013281
Inhibitory effects of aurentiacin from Syzygium samarangense on lipopolysaccharide-induced inflammatory response in mouse macrophages.	2012-03	22155221
Anti-tumor effects by a synthetic chalcone compound is mediated by c-Myc-mediated reactive oxygen species production.	2010-10-06	20620131
Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile.	2007-03-20	17320913
Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives.	2007-03-15	17276682
Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.	2007-01	17007965
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006-11	16497524
Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.	2005-08	15863696
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.	2003-10	14565775
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase.	2001-11-02	11524419
In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall.	2001-08	11504637
Inhibition of HIV activation in latently infected cells by flavonoid compounds.	1996-01-01	8825617
Commonly occurring plant flavonoids have estrogenic activity.	1993-07	8341277
Aspects of the metabolism of the peripheral vasodilator mecinarone (14C-6809 MD) in rat, dog and man.	1980	7202432

Patents

Name

Type

Language

CHALCONE

Systematic Name

English

NSC-167107

Preferred Name

English

NSC-26612

Code

English

CINNAMOPHENONE

Systematic Name

English

(E)-CHALCONE

Systematic Name

English

CHALCONE, (E)-

Systematic Name

English

BENZALACETOPHENONE

Systematic Name

English

BENZYLIDENEACETOPHENONE

Systematic Name

English

CHALCONE [MI]

Common Name

English

CHALCONE (E)-FORM [MI]

Common Name

English

NSC-4523

Code

English

PHENYL (E)-2-PHENYLETHENYL KETONE

Systematic Name

English

PHENYL 2-PHENYLVINYL KETONE

Systematic Name

English

1,3-DIPHENYL-2-PROPEN-1-ONE

Systematic Name

English

PHENYL STYRYL KETONE

Systematic Name

English

2-PROPEN-1-ONE, 1,3-DIPHENYL-

Systematic Name

English

CHALKONE

Common Name

English

PHENYL TRANS-STYRYL KETONE

Systematic Name

English

3-PHENYLACRYLOPHENONE

Systematic Name

English

PHENYL (E)-STYRYL KETONE

Systematic Name

English

2-PROPEN-1-ONE, 1,3-DIPHENYL-, (2E)-

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

210-383-8