IPROPLATIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C3H9N.2Cl.Pt.2HO
Molecular Weight	418.225
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-4

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].[OH-].[Cl-].[Cl-].[Pt].CC(C)N.CC(C)N

InChI

InChIKey=AGFPKKCNKJRESC-UHFFFAOYSA-J

InChI=1S/2C3H9N.2ClH.2H2O.Pt/c2*1-3(2)4;;;;;/h2*3H,4H2,1-2H3;2*1H;2*1H2;/p-4

HIDE SMILES / InChI

Description
Sources: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/iproplatin | https://www.ncbi.nlm.nih.gov/pubmed/17707553 | https://www.ncbi.nlm.nih.gov/pubmed/2590996

IPROPLATIN is a quadrivalent second-generation platinum complex. It binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and tumor cell death. IPROPLATIN was discontinued in phase III clinical trials.

Originator

Approval Year

PubMed

Title	Date	PubMed
Carboplatin (CBDCA), iproplatin (CHIP), and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity.	1987	2880677
Studies on the human metabolism of iproplatin.	1989	2590996
Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs.	1992 Oct 15	1394205
Insight into the reactive form of the anticancer agent iproplatin.	2008 May	17707553

Name

Type

Language

IPROPLATIN

Official Name

English

JM-9

Code

English

CHIP

Common Name

English

PLATINUM, DICHLORODIHYDROXYBIS(2-PROPANAMINE)-, (OC-6-33)

Common Name

English

IPROPLATIN [USAN]

Common Name

English

NSC-256927

Code

English

IPROPLATIN [MART.]

Common Name

English

Iproplatin [WHO-DD]

Common Name

English

iproplatin [INN]

Common Name

English

ab-Dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1450