U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H22N4O4
Molecular Weight 334.3703
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TETROXOPRIM

SMILES

COCCOC1=C(OC)C=C(CC2=C(N)N=C(N)N=C2)C=C1OC

InChI

InChIKey=WSWJIZXMAUYHOE-UHFFFAOYSA-N
InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)

HIDE SMILES / InChI
Tetroxoprim is an inhibitor of bacterial dihydrofolate reductase. In combination with sulfadiazine (co-tetroxazine) it has been used for the treatment of susceptible bacterial infections.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P0ABQ4
Gene ID: 944790.0
Gene Symbol: folA
Target Organism: Escherichia coli (strain K12)
3.2 nM [Ki]
PubMed

PubMed

TitleDatePubMed
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
1995 Nov 24
Order-disorder enantiotropy, monotropy, and isostructurality in a tetroxoprim-sulfametrole 1:1 molecular complex: Crystallographic and thermal studies.
2003 Nov
Name Type Language
TETROXOPRIM
INN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
tetroxoprim [INN]
Common Name English
TETROXOPRIM [MART.]
Common Name English
Tetroxoprim [WHO-DD]
Common Name English
2,4-Diamino-5-[3,5-dimethoxy-4-(2-methoxyethoxy)benzyl]pyrimidine
Systematic Name English
TETROXOPRIM [USAN]
Common Name English
TETROXOPRIM [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2153
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
WHO-ATC J01EE06
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
Code System Code Type Description
PUBCHEM
65450
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY
WIKIPEDIA
TETROXOPRIM
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY
INN
3814
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL32039
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY
NCI_THESAURUS
C76644
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
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CAS
53808-87-0
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY
ECHA (EC/EINECS)
258-789-4
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
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MESH
C023507
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
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EPA CompTox
DTXSID80202085
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
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EVMPD
SUB10953MIG
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
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SMS_ID
100000082722
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY
RXCUI
37999
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
2615
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
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MERCK INDEX
m10668
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY Merck Index
FDA UNII
5R6712AY0K
Created by admin on Fri Dec 15 15:47:23 GMT 2023 , Edited by admin on Fri Dec 15 15:47:23 GMT 2023
PRIMARY