Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H16O4.C17H19ClN2S |
| Molecular Weight | 639.203 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2.OC(=O)C4=C(C=CC=C4)C(C5=CC=C(O)C=C5)C6=CC=C(O)C=C6
InChI
InChIKey=ZRZQLIGMSARLBW-UHFFFAOYSA-N
InChI=1S/C20H16O4.C17H19ClN2S/c21-15-9-5-13(6-10-15)19(14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)20(23)24;1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h1-12,19,21-22H,(H,23,24);3-4,6-9,12H,5,10-11H2,1-2H3
Chlorpromazine Phenolphthalinate is Phenolphthalinate salt of psychotropic agent Chlorpromazine marketed as Wintermin by Japanese pharmaceutical company Shionogi Inc for treating certain mental or mood disorders. Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia and other central nervous system disease
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| THE EFFECT OF L-3, 4-DIHYDROXYPHENYLALANINE AND DL-5-HYDROXYTRYPTOPHAN ON RIGIDITY AND TREMOR INDUCED BY RESERPINE, CHLORPROMAZINE AND PHENOXYBENZAMINE. | 1964 Apr |
|
| Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. | 1992 |
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| Chlorpromazine: a drug potentially useful for treating mycobacterial infections. | 1992 |
|
| Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor. | 1992 Apr 10 |
|
| An unusual cause of convulsions in a newborn infant. | 1992 Dec |
|
| Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. | 1992 Jul |
|
| Muscle pains and biochemical changes following suxamethonium administration after six pretreatment regimens. | 1992 Mar |
|
| [A case of neuroleptic malignant syndrome with acute renal failure]. | 1992 Nov |
|
| Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | 1992 Sep |
|
| Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. | 2003 Aug 1 |
|
| Dual action of oestrogens on the mouse constitutive androstane receptor. | 2003 Dec 1 |
|
| [Reversal of multidrug resistance in leukemic cell line K562/AO2 by chlordelazine in vitro]. | 2003 Jul |
|
| QTc prolongation: chlorpromazine and high-dosage olanzapine. | 2003 Jun |
|
| The antipsychotic drug chlorpromazine inhibits HERG potassium channels. | 2003 Jun |
|
| Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. | 2003 Jun |
|
| The steroid-responsive hiccup reflex arc: competitive binding to the corticosteroid-receptor? | 2003 Jun-Aug |
|
| Variant Creutzfeldt-Jakob disease. | 2003 Mar |
|
| H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. | 2003 Mar |
|
| New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. | 2003 May 10 |
|
| Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics. | 2003 Oct |
|
| Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis. | 2003 Oct 24 |
|
| Sydenham's chorea may be a risk factor for drug induced parkinsonism. | 2003 Sep |
|
| [Differences in prooxidant effect of neuroleptics haloperidol and aminazine]. | 2003 Sep-Oct |
|
| UVA activated 8-MOP and chlorpromazine inhibit release of TNF-alpha by post-transcriptional regulation. | 2004 Apr |
|
| Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. | 2004 Apr 15 |
|
| Two cases of deep vein thrombosis associated with antipsychotic drug use. | 2004 Aug |
|
| Valproate-induced hyperammonemic encephalopathy. | 2004 Aug |
|
| Effects of lipopolysaccharide and chlorpromazine on glucocorticoid receptor-mediated gene transcription and immunoreactivity: a possible involvement of p38-MAP kinase. | 2004 Dec |
|
| Smoking impact on CYP1A2 activity in a group of patients with schizophrenia. | 2004 Jan |
|
| Spasmodic dysphonia, a rare form of tardive dystonia, induced by low-dose risperidone? | 2004 Mar |
|
| Drug-induced liver injury. | 2004 Mar 1 |
|
| Block of HERG human K(+) channel and IKr of guinea pig cardiomyocytes by chlorpromazine. | 2004 May |
|
| Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine. | 2004 Oct |
|
| Oral terbutaline in the management of pharmacologically induced prolonged erection. | 2004 Oct |
|
| The phenothiazine drugs inhibit hERG potassium channels. | 2005 |
|
| Intraoperative preparation of the radial artery for coronary artery bypass grafting. | 2005 |
|
| Invited review: fluphenazine augments retinal oxidative stress. | 2005 Aug |
|
| Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. | 2005 Aug 4 |
|
| Non-paracetamol drug-induced fulminant hepatic failure among adults in Scotland. | 2005 Feb |
|
| A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. | 2005 Feb |
|
| New inhibitors of the Tat-TAR RNA interaction found with a "fuzzy" pharmacophore model. | 2005 Jun |
|
| Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. | 2005 Mar 7 |
|
| [Thanatogenesis in poisoning with psychopharmaceuticals]. | 2005 Mar-Apr |
|
| Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs. | 2005 May |
|
| Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates. | 2005 Nov |
|
| The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system. | 2005 Sep 1 |
|
| Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinases. | 2006 Apr |
|
| Effect of chlorpromazine on bone sialoprotein (BSP) gene transcription. | 2006 Apr 15 |
|
| Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 Feb 1 |
|
| Frequency of high-risk use of QT-prolonging medications. | 2006 Jun |
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SUBSTANCE RECORD
