U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H19N3S
Molecular Weight 285.407
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROTHIPENDYL

SMILES

CN(C)CCCN1C2=C(SC3=C1N=CC=C3)C=CC=C2

InChI

InChIKey=JTTAUPUMOLRVRA-UHFFFAOYSA-N
InChI=1S/C16H19N3S/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19/h3-5,7-10H,6,11-12H2,1-2H3

HIDE SMILES / InChI
PROTHIPENDYL is a neuroleptic azaphenothiazine used to treat anxiety and agitation in psychotic syndromes. It also shows strong antihistamine and anti-emetic actions.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
18 ng/mL
40 mg single, oral
dose: 40 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PROTHIPENDYL serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
42.6 ng/mL
80 mg single, oral
dose: 80 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PROTHIPENDYL serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.5 h
unknown, oral
PROTHIPENDYL unknown
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1280 mg 1 times / day multiple, oral
Studied dose
Dose: 1280 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1280 mg, 1 times / day
Sources:
unhealthy, 20 years (range: 16-31 years)
n = 10
Health Status: unhealthy
Condition: long-standing behaviour disorders
Age Group: 20 years (range: 16-31 years)
Sex: M
Population Size: 10
Sources:
960 mg 1 times / day multiple, oral
Studied dose
Dose: 960 mg, 1 times / day
Route: oral
Route: multiple
Dose: 960 mg, 1 times / day
Sources:
unhealthy, 26 years (range: 14-42 years)
n = 10
Health Status: unhealthy
Condition: long-standing behaviour disorders
Age Group: 26 years (range: 14-42 years)
Sex: F
Population Size: 10
Sources:
4 g single, oral
Overdose
Dose: 4 g
Route: oral
Route: single
Dose: 4 g
Sources:
unknown
Health Status: unknown
Sources:
Other AEs: Adverse event...
Other AEs:
Adverse event (grade 5)
Sources:
AEs

AEs

AESignificanceDosePopulation
Adverse event grade 5
4 g single, oral
Overdose
Dose: 4 g
Route: oral
Route: single
Dose: 4 g
Sources:
unknown
Health Status: unknown
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as victim
PubMed

PubMed

TitleDatePubMed
Name Type Language
PROTHIPENDYL
INN   MI   WHO-DD  
INN  
Official Name English
PROTHIPENDYL [MI]
Common Name English
prothipendyl [INN]
Common Name English
Prothipendyl [WHO-DD]
Common Name English
N,N-DIMETHYL-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-PROPANAMINE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
WHO-VATC QN05AX07
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
WHO-ATC N05AX07
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
Code System Code Type Description
WIKIPEDIA
PROTHIPENDYL
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
MESH
C069248
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
FDA UNII
5O6VWA87VA
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
SMS_ID
100000080835
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
ChEMBL
CHEMBL2111030
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
CAS
303-69-5
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
INN
691
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
RXCUI
55244
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB12958
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
NCI_THESAURUS
C84124
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
PUBCHEM
14670
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
EVMPD
SUB10138MIG
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
EPA CompTox
DTXSID50184389
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY
MERCK INDEX
M9268
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY Merck Index
DRUG CENTRAL
2315
Created by admin on Wed Jul 05 22:58:06 UTC 2023 , Edited by admin on Wed Jul 05 22:58:06 UTC 2023
PRIMARY