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Details

Stereochemistry EPIMERIC
Molecular Formula C24H28NO4
Molecular Weight 394.4834
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 5
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of PHENACTROPINIUM

SMILES

[H][C@]12CC[C@]([H])(C[C@@H](C1)OC(=O)C(O)C3=CC=CC=C3)[N+]2(C)CC(=O)C4=CC=CC=C4

InChI

InChIKey=REFUXNZBPJQVLU-VLBFHQNGSA-N
InChI=1S/C24H28NO4/c1-25(16-22(26)17-8-4-2-5-9-17)19-12-13-20(25)15-21(14-19)29-24(28)23(27)18-10-6-3-7-11-18/h2-11,19-21,23,27H,12-16H2,1H3/q+1/t19-,20+,21+,23?,25?

HIDE SMILES / InChI

Description

PHENACTROPINIUM (TROPHENIUM®), a tropinium ester, is an agent for the production of controlled hypotension during general anesthesia, providing ganglion blockade without direct vasodilator action.

Originator

Approval Year

1961
146
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Trophenium

Approved Use

Antihypertensive

Launch Date

1960
Sourcing

Sourcing

Vendor/AggregatorIDURL
BOC Sciences
3784-89-2
ChEMBL
CHEMBL2111125
ChemIDplus
697214894
https://chem.nlm.nih.gov/chemidplus/id/0697214894
Tetrahedron
TS81930
Wikidata
Q27262617
ZINC
ZINC000261506652
http://zinc15.docking.org/substances/ZINC000261506652
ZINC
ZINC000261506653
http://zinc15.docking.org/substances/ZINC000261506653
ZINC
ZINC000261506654
http://zinc15.docking.org/substances/ZINC000261506654
ZINC
ZINC000261506655
http://zinc15.docking.org/substances/ZINC000261506655
PubMed

PubMed

TitleDatePubMed
The use of a homatropinium derivative to produce controlled hypotension.
1957 Aug
The use of fluothane and trophenium in anaesthesia for the surgery of deafness.
1958 Dec
Phenactropinium chloride; clinical observations.
1961 Jan
Patents

Patents

4898888
2
Name Type Language
PHENACTROPINIUM
Common Name English
PHENACTROPINIUM ION
Common Name English
8-AZONIABICYCLO(3.2.1)OCTANE, 3-((HYDROXYPHENYLACETYL)OXY)-8-METHYL-8-(2-OXO-2-PHENYLETHYL)-, (3-EXO)-
Common Name English
PHENACTROPINIUM CATION
Common Name English
N-PHENACYLHOMATROPINIUM
Common Name English
Code System Code Type Description
FDA UNII
5O3E9EBA8Q
Created by admin on Sat Dec 16 05:15:45 GMT 2023 , Edited by admin on Sat Dec 16 05:15:45 GMT 2023
PRIMARY
CAS
697214-89-4
Created by admin on Sat Dec 16 05:15:45 GMT 2023 , Edited by admin on Sat Dec 16 05:15:45 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of PHENACTROPINIUM
NIH
NCATS
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