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Details

Stereochemistry ACHIRAL
Molecular Formula C10H11I2NO3
Molecular Weight 447.0082
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYLIODONE

SMILES

CCCOC(=O)CN1C=C(I)C(=O)C(I)=C1

InChI

InChIKey=ROSXARVHJNYYDO-UHFFFAOYSA-N
InChI=1S/C10H11I2NO3/c1-2-3-16-9(14)6-13-4-7(11)10(15)8(12)5-13/h4-5H,2-3,6H2,1H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including:

Propyliodone (INN, trade name Dionosil) is a molecule used as a contrast medium. It was developed by a team at Imperial Chemical Industries in the late 1930s. Propyliodone used as radiopque medium for brochographic use. When directly instilled into the bronchi resulting in well-defined bronchograms for atleast 30 min. Because of its toxicity, Propyliodone should only be used if absolutely essential. It is of Synthetic origin and belongs to Iodinated Radio-opaque Compounds. It belongs to Radiopaque Agents pharmacological group on the basis of mechanism of action and also classified in Diagnostic Aids pharmacological group. Oral absorption of Propyliodone is found to be 101% and metabolism is reported Lungs and Gut wall. Propyliodone is primarily indicated in conditions like Paget's disease of bone, Radiological contrast agent. Propyliodone produces potentially life-threatening effects which include Fever, Anaphylaxis, Repiratory obstruction, Cerebral embolization, which are responsible for the discontinuation of Propyliodone therapy. The signs and symptoms that are produced after the acute overdosage of Propyliodone include Airway obstruction. The symptomatic adverse reactions produced by Propyliodone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fever, Malaise, Nausea and vomiting, Aching joints.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
DIONOSIL OILY

Approved Use

Propyliodone
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Intratracheal
In Vitro Use Guide
Unknown
Name Type Language
PROPYLIODONE
INN   JAN   MART.   MI   ORANGE BOOK   USP   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
PROPYLIODONUM [WHO-IP LATIN]
Common Name English
NSC-97103
Code English
propyliodone [INN]
Common Name English
PROPYLIODONE [ORANGE BOOK]
Common Name English
PROPYLIODONE [VANDF]
Common Name English
PROPYLIODONE [USP IMPURITY]
Common Name English
Propyl 3,5-diiodo-4-oxo-1(4H) pyridineacetate
Systematic Name English
DIONOSIL
Common Name English
PROPYLIODONE [WHO-IP]
Common Name English
PROPYLIODONE [MART.]
Common Name English
PROPYLIODONE [JAN]
Common Name English
1(4H)-PYRIDINEACETIC ACID, 3,5-DIIODO-4-OXO-, PROPYL ESTER
Common Name English
DIONOSIL OILY
Brand Name English
Propyliodone [WHO-DD]
Common Name English
A. G. 33-107
Code English
PROPYLIODONE [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C390
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
WHO-ATC V08AD03
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
WHO-VATC QV08AD03
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
Code System Code Type Description
NSC
97103
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
CAS
587-61-1
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200821
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
PUBCHEM
4949
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
WIKIPEDIA
PROPYLIODONE
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
MESH
D011440
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
PROPYLIODONE
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Practically insoluble in water; slightly soluble in ethanol (~750 g/l) TS; very slightly soluble in ether R. Category: Radiocontrast medium. Storage: Propyliodone should be kept in a tightly closed container, protected from light. Requirement: Propyliodone contains not less than 99.0% and not more than the equivalent of 101.0% of C10H11I2NO3, calculated withreference to the dried substance.
SMS_ID
100000081383
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
NCI_THESAURUS
C66494
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
ECHA (EC/EINECS)
209-603-5
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
EVMPD
SUB10122MIG
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
DRUG BANK
DB09366
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID6023527
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
MERCK INDEX
m1241
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY Merck Index
INN
4183
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
RXCUI
8793
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY RxNorm
FDA UNII
5NPJ6BPX36
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY
DRUG CENTRAL
2306
Created by admin on Sat Dec 16 17:59:02 GMT 2023 , Edited by admin on Sat Dec 16 17:59:02 GMT 2023
PRIMARY