Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C22H28N2O5S |
Molecular Weight | 432.533 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CCC[C@H](N1C(=O)[C@H](CC3=CC=CC=C23)NC(=O)[C@@H](SC(C)=O)C(C)C)C(O)=O
InChI
InChIKey=FXKFFTMLFPWYFH-RDGPPVDQSA-N
InChI=1S/C22H28N2O5S/c1-12(2)19(30-13(3)25)20(26)23-16-11-14-7-4-5-8-15(14)17-9-6-10-18(22(28)29)24(17)21(16)27/h4-5,7-8,12,16-19H,6,9-11H2,1-3H3,(H,23,26)(H,28,29)/t16-,17+,18-,19-/m0/s1
Ilepatril, previously known as AVE7688, an inhibitor of neutral endopeptidase and angiotensin-converting enzyme (ACE), was initially being developed for cardiac failure. Ilepatril was in phase IIb/III clinical trials for hypertension and in phase II trials for diabetic nephropathy, however, studies were discontinued.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00284128
oral administration (capsules)(2.5 or 10 or 35 or 50 mg ) once daily
Route of Administration:
Oral
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NCI_THESAURUS |
C270
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C87731
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8766
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ACTIVE MOIETY